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Entries
NoRC negatively regulates rRNA expression
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authored
[InstanceEdit:427381] May, B, 2009-06-19
compartment
[Compartment:7660] nucleoplasm
created
[InstanceEdit:427372] May, B, 2009-06-19
dbId
427413
displayName
NoRC negatively regulates rRNA expression
doi
10.3180/REACT_200856.1
edited
[InstanceEdit:565730] May, B, 2010-04-06
eventOf
[Pathway:R-HSA-5250941] Negative epigenetic regulation of rRNA expression - Homo sapiens
goBiologicalProcess
[GO_BiologicalProcess:21778] rDNA heterochromatin formation
hasDiagram
true
hasEHLD
false
hasEvent
[BlackBoxEvent:R-HSA-427366] Transcription of intergenic spacer of the rRNA gene - Homo sapiens
[BlackBoxEvent:R-HSA-427394] Cleavage of intergenic spacer RNA to yield fragments of 150-300 nucleotides - Homo sapiens
[Reaction:R-HSA-74987] TTF-I binds to the Sal Box - Homo sapiens
[Reaction:R-HSA-427409] Nucleolar Remodelling Complex (NoRC) binds intergenic region of rDNA - Homo sapiens
[BlackBoxEvent:R-HSA-433672] NoRC:HDAC:DNMT deacetylates histone H4 and methylates histone H3 - Homo sapiens
[Reaction:R-HSA-5227490] NoRC:HDAC:DNMT methylates cytosine of the rRNA genes - Homo sapiens
[Reaction:R-HSA-427337] MBD2 binds methylcytosine in chromatin - Homo sapiens
isInDisease
false
isInferred
false
lastUpdatedDate
2018-12-13
literatureReference
[LiteratureReference:427392] The epigenetics of rRNA genes: from molecular to chromosome biology
[LiteratureReference:427385] Different epigenetic layers engage in complex crosstalk to define the epigenetic state of mammalian rRNA genes
[LiteratureReference:427388] Molecular mechanisms mediating methylation-dependent silencing of ribosomal gene transcription
[LiteratureReference:427414] Structure and function of ribosomal RNA gene chromatin
[LiteratureReference:427323] rRNA gene silencing and nucleolar dominance: insights into a chromosome-scale epigenetic on/off switch
[LiteratureReference:5096457] Epigenetic control of RNA polymerase I transcription in mammalian cells
maxDepth
2
modified
[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name
NoRC negatively regulates rRNA expression
Methylation of histones and DNA negatively regulates rRNA expression
orthologousEvent
[Pathway:R-DME-427413] NoRC negatively regulates rRNA expression - Drosophila melanogaster
[Pathway:R-GGA-427413] NoRC negatively regulates rRNA expression - Gallus gallus
[Pathway:R-DRE-427413] NoRC negatively regulates rRNA expression - Danio rerio
[Pathway:R-BTA-427413] NoRC negatively regulates rRNA expression - Bos taurus
[Pathway:R-CFA-427413] NoRC negatively regulates rRNA expression - Canis familiaris
[Pathway:R-RNO-427413] NoRC negatively regulates rRNA expression - Rattus norvegicus
releaseDate
2014-03-12
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:5332991] Shiao, YH, 2014-02-18
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-427413
summation
[Summation:9034619] The Nucleolar Remodeling Complex (NoRC) comprising TIP5 (BAZ...
updateTrackers
[UpdateTracker:9864139] Update Tracker - [Pathway:427413] NoRC negatively regulates rRNA expression - v88:[updateContainedRLE]
[UpdateTracker:9780158] Update Tracker - [Pathway:427413] NoRC negatively regulates rRNA expression - v64:[add_removeSummation, updateContainedRLE]
[UpdateTracker:9778736] Update Tracker - [Pathway:427413] NoRC negatively regulates rRNA expression - v67:[updateContainedRLE]
[UpdateTracker:9779195] Update Tracker - [Pathway:427413] NoRC negatively regulates rRNA expression - v66:[updateContainedRLE]
Referrals
(updatedInstance)
[UpdateTracker:9864139] Update Tracker - [Pathway:427413] NoRC negatively regulates rRNA expression - v88:[updateContainedRLE]
[UpdateTracker:9780158] Update Tracker - [Pathway:427413] NoRC negatively regulates rRNA expression - v64:[add_removeSummation, updateContainedRLE]
[UpdateTracker:9778736] Update Tracker - [Pathway:427413] NoRC negatively regulates rRNA expression - v67:[updateContainedRLE]
[UpdateTracker:9779195] Update Tracker - [Pathway:427413] NoRC negatively regulates rRNA expression - v66:[updateContainedRLE]
(hasEvent)
[Pathway:R-HSA-5250941] Negative epigenetic regulation of rRNA expression
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