Reactome | PLCG1 disassociates from VEGFR2 and translocate to PM

authored	[InstanceEdit:4420157] Garapati, P V, 2013-08-30
category	dissociation
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:4420157] Garapati, P V, 2013-08-30
dbId	4420202
displayName	PLCG1 disassociates from VEGFR2 and translocate to PM
edited	[InstanceEdit:4420157] Garapati, P V, 2013-08-30
eventOf	[Pathway:R-HSA-5218921] VEGFR2 mediated cell proliferation - Homo sapiens
followingEvent	[Reaction:R-HSA-167686] Active PLCG1 hydrolyses PIP2 - Homo sapiens
input	[Complex:R-HSA-4420110] VEGFA dimer:p-6Y-VEGFR2 dimer:p-4Y-PLCG1 [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:195484] A single autophosphorylation site on KDR/Flk-1 is essential for VEGF-A-dependent activation of PLC-gamma and DNA synthesis in vascular endothelial cells [LiteratureReference:4420118] Role of PLCgamma and Ca(2+) in VEGF- and FGF-induced choroidal endothelial cell proliferation
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	PLCG1 disassociates from VEGFR2 and translocate to PM
orthologousEvent	[Reaction:R-GGA-4420202] PLCG1 disassociates from VEGFR2 and translocate to PM - Gallus gallus [Reaction:R-XTR-4420202] PLCG1 disassociates from VEGFR2 and translocate to PM - Xenopus tropicalis [Reaction:R-DRE-4420202] PLCG1 disassociates from VEGFR2 and translocate to PM - Danio rerio [Reaction:R-SSC-4420202] PLCG1 disassociates from VEGFR2 and translocate to PM - Sus scrofa [Reaction:R-BTA-4420202] PLCG1 disassociates from VEGFR2 and translocate to PM - Bos taurus [Reaction:R-CFA-4420202] PLCG1 disassociates from VEGFR2 and translocate to PM - Canis familiaris [Reaction:R-RNO-4420202] PLCG1 disassociates from VEGFR2 and translocate to PM - Rattus norvegicus [Reaction:R-MMU-4420202] PLCG1 disassociates from VEGFR2 and translocate to PM - Mus musculus
output	[EntityWithAccessionedSequence:R-HSA-167679] p-4Y-PLCG1 [plasma membrane] [Complex:R-HSA-4420101] VEGFA dimer:p-6Y-VEGFR2 dimer [plasma membrane]
precedingEvent	[Reaction:R-HSA-4420121] SFKs phosphorylate PLCG1 - Homo sapiens
releaseDate	2014-06-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5432673] Welsh, Michael, Berger, Philipp, Ballmer-Hofer, Kurt, 2014-05-12
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-4420202
summation	[Summation:4420175] Following tyrosine phosphorylation and activation, PLCG1 dis...

PLCG1 disassociates from VEGFR2 and translocate to PM Show undefined attributes

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