Reactome | VEGFR2 mediated cell proliferation

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VEGFR2 mediated cell proliferation Show undefined attributes

compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:11051501] Weiser, Joel, 2026-03-16
dbId	11079479
displayName	VEGFR2 mediated cell proliferation
eventOf	[Pathway:R-SPO-4420097] VEGFA-VEGFR2 Pathway - Schizosaccharomyces pombe
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-SPO-5218821] PDK1 phosphorylates PKC - Schizosaccharomyces pombe [Reaction:R-SPO-5218805] PKC autophosphorylates - Schizosaccharomyces pombe [Reaction:R-SPO-5218813] DAG and Ca+2 bind to PKC and tether it to membrane - Schizosaccharomyces pombe [Reaction:R-SPO-5218823] PKC phosphorylates sphingosine kinase 1 - Schizosaccharomyces pombe
inferredFrom	[Pathway:R-HSA-5218921] VEGFR2 mediated cell proliferation - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	VEGFR2 mediated cell proliferation
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:68324] Schizosaccharomyces pombe
stId	R-SPO-5218921
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SPO-4420097] VEGFA-VEGFR2 Pathway
(inferredTo)	[Pathway:R-HSA-5218921] VEGFR2 mediated cell proliferation

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