Reactome | p-6Y-VEGFR2 binds PLCG1

Schema > Reaction > Entries

p-6Y-VEGFR2 binds PLCG1 Show undefined attributes

authored	[InstanceEdit:4420157] Garapati, P V, 2013-08-30
category	binding
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:4420157] Garapati, P V, 2013-08-30
dbId	4420153
displayName	p-6Y-VEGFR2 binds PLCG1
edited	[InstanceEdit:4420157] Garapati, P V, 2013-08-30
eventOf	[Pathway:R-HSA-5218921] VEGFR2 mediated cell proliferation - Homo sapiens
followingEvent	[Reaction:R-HSA-4420121] SFKs phosphorylate PLCG1 - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-202320] PLCG1 [cytosol] [Complex:R-HSA-4420101] VEGFA dimer:p-6Y-VEGFR2 dimer [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:4420118] Role of PLCgamma and Ca(2+) in VEGF- and FGF-induced choroidal endothelial cell proliferation [LiteratureReference:195484] A single autophosphorylation site on KDR/Flk-1 is essential for VEGF-A-dependent activation of PLC-gamma and DNA synthesis in vascular endothelial cells
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	p-6Y-VEGFR2 binds PLCG1
negativePrecedingEvent	[NegativePrecedingEvent:9865998] Futile Cycle: PLCG1 disassociates from VEGFR2 and translocate to PM
orthologousEvent	[Reaction:R-GGA-4420153] p-6Y-VEGFR2 binds PLCG1 - Gallus gallus [Reaction:R-XTR-4420153] p-6Y-VEGFR2 binds PLCG1 - Xenopus tropicalis [Reaction:R-DRE-4420153] p-6Y-VEGFR2 binds PLCG1 - Danio rerio [Reaction:R-SSC-4420153] p-6Y-VEGFR2 binds PLCG1 - Sus scrofa [Reaction:R-BTA-4420153] p-6Y-VEGFR2 binds PLCG1 - Bos taurus [Reaction:R-CFA-4420153] p-6Y-VEGFR2 binds PLCG1 - Canis familiaris [Reaction:R-RNO-4420153] p-6Y-VEGFR2 binds PLCG1 - Rattus norvegicus [Reaction:R-MMU-4420153] p-6Y-VEGFR2 binds PLCG1 - Mus musculus
output	[Complex:R-HSA-4420203] VEGFA dimer:p-6Y-VEGFR2 dimer:PLCG1 [plasma membrane]
precedingEvent	[Reaction:R-HSA-4420117] VEGFR2 autophosphorylates - Homo sapiens
releaseDate	2014-06-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5432673] Welsh, Michael, Berger, Philipp, Ballmer-Hofer, Kurt, 2014-05-12
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-4420153
summation	[Summation:4420112] Phospholipase C-gamma 1 (PLCG1) plays a pivotal role in angi...

Referrals

(hasEvent)	[Pathway:R-HSA-5218921] VEGFR2 mediated cell proliferation
(precedingEvent)	[Reaction:R-HSA-4420121] SFKs phosphorylate PLCG1