Reactome | Pink1 is cleaved on healthy mitochondria

Schema > Reaction > Entries

category	transition
compartment	[Compartment:17927] mitochondrial intermembrane space
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10876403
displayName	Pink1 is cleaved on healthy mitochondria
eventOf	[Pathway:R-DME-5205685] PINK1-PRKN Mediated Mitophagy - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-5205681] Pink1 is cleaved on healthy mitochondria - Homo sapiens
input	[EntityWithAccessionedSequence:R-DME-5205671] PINK1 [mitochondrial intermembrane space]
isInDisease	false
isInferred	true
maxDepth	1
name	Pink1 is cleaved on healthy mitochondria
output	[EntityWithAccessionedSequence:R-DME-5205628] PINK1(111-581) [mitochondrial intermembrane space]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-5205681
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-DME-5205685] PINK1-PRKN Mediated Mitophagy
(inferredTo)	[Reaction:R-HSA-5205681] Pink1 is cleaved on healthy mitochondria

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