Pink1 is cleaved on healthy mitochondria

Stable Identifier
R-HSA-5205681
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Full-length PINK1 (63 kDa), which is in the inner mitochondrial space, is proteolytically cleaved into an 52-kDa cytosolic fragment (111 - 581) that is released back into the cytoplasm by an unknown mechanism and degraded by the proteasome. cleavage of PINK1 into an unstable cytosolic form maintains low levels of PINK1 on healthy mitochondria in order to suppress the PINK1/Parkin pathway in the absence of mitochondrial damage. At present, not all of the proteases mediating the cleavage of PINK1 in mammalian cells have been identified.

Literature References
PubMed ID Title Journal Year
21115803 Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL

Jin, SM, Lazarou, M, Wang, C, Kane, LA, Narendra, DP, Youle, RJ

J. Cell Biol. 2010
20126261 PINK1 is selectively stabilized on impaired mitochondria to activate Parkin

Narendra, DP, Jin, SM, Tanaka, A, Suen, DF, Gautier, CA, Shen, J, Cookson, MR, Youle, RJ

PLoS Biol. 2010
21194381 Targeting mitochondrial dysfunction: role for PINK1 and Parkin in mitochondrial quality control

Narendra, DP, Youle, RJ

Antioxid. Redox Signal. 2011
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