Reactome | Pink1 is cleaved on healthy mitochondria

Pink1 is cleaved on healthy mitochondria

Stable Identifier

R-HSA-5205681

Type

Reaction [transition]

Species

Homo sapiens

Compartment

mitochondrial intermembrane space

ReviewStatus

5/5

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Pink1 is cleaved on healthy mitochondria

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Full-length PINK1 (63 kDa), which is in the inner mitochondrial space, is proteolytically cleaved into a 52-kDa cytosolic fragment (111 - 581) that is released back into the cytoplasm by an unknown mechanism and degraded by the proteasome. Cleavage of PINK1 into an unstable cytosolic form maintains low levels of PINK1 on healthy mitochondria in order to suppress the PINK1/Parkin pathway in the absence of mitochondrial damage. At present, not all of the proteases mediating the cleavage of PINK1 in mammalian cells have been identified.

Literature References

PubMed ID	Title	Journal	Year
20126261	PINK1 is selectively stabilized on impaired mitochondria to activate Parkin Tanaka, A, Jin, SM, Cookson, MR, Narendra, DP, Suen, DF, Shen, J, Youle, RJ, Gautier, CA	PLoS Biol.	2010
21115803	Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL Kane, LA, Jin, SM, Wang, C, Narendra, DP, Lazarou, M, Youle, RJ	J. Cell Biol.	2010
21194381	Targeting mitochondrial dysfunction: role for PINK1 and Parkin in mitochondrial quality control Narendra, DP, Youle, RJ	Antioxid. Redox Signal.	2011