Full-length PINK1 (63 kDa), which is in the inner mitochondrial space, is proteolytically cleaved into an 52-kDa cytosolic fragment (111 - 581) that is released back into the cytoplasm by an unknown mechanism and degraded by the proteasome. Cleavage of PINK1 into an unstable cytosolic form maintains low levels of PINK1 on healthy mitochondria in order to suppress the PINK1/Parkin pathway in the absence of mitochondrial damage. At present, not all of the proteases mediating the cleavage of PINK1 in mammalian cells have been identified.
Tanaka, A, Jin, SM, Cookson, MR, Narendra, DP, Suen, DF, Shen, J, Youle, RJ, Gautier, CA
Kane, LA, Jin, SM, Wang, C, Narendra, DP, Lazarou, M, Youle, RJ
Narendra, DP, Youle, RJ
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