Pink1 is recruited from the cytoplasm to the mitochondria

Stable Identifier
R-HSA-5205661
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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PINK1 is constitutively synthesized and imported into all mitochondria. In healthy mitochondria PINK1 is cleaved by voltage-sensitive proteolysis.

Literature References
PubMed ID Title Journal Year
20126261 PINK1 is selectively stabilized on impaired mitochondria to activate Parkin

Narendra, DP, Jin, SM, Tanaka, A, Suen, DF, Gautier, CA, Shen, J, Cookson, MR, Youle, RJ

PLoS Biol. 2010
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein transmembrane transporter activity of TOMM40 Complex [mitochondrial outer membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created