Pink1 is recruited from the cytoplasm to the mitochondria

Stable Identifier
R-HSA-5205661
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Pink1 is recruited from the cytoplasm to the mitochondria
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
PINK1 is constitutively synthesized and imported into all mitochondria. In healthy mitochondria PINK1 is cleaved by voltage-sensitive proteolysis.
Literature References
PubMed ID Title Journal Year
20126261 PINK1 is selectively stabilized on impaired mitochondria to activate Parkin

Narendra, DP, Jin, SM, Tanaka, A, Suen, DF, Gautier, CA, Shen, J, Cookson, MR, Youle, RJ

PLoS Biol. 2010
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein transmembrane transporter activity of TOMM40 Complex [mitochondrial outer membrane]

Physical Entity
TOMM40 Complex [mitochondrial outer membrane] (Homo sapiens)
Activity
protein transmembrane transporter activity (GO:0008320)
Orthologous Events
Pink1 is recruited from the cytoplasm to the mitochondria (Bos taurus)
Pink1 is recruited from the cytoplasm to the mitochondria (Canis familiaris)
Pink1 is recruited from the cytoplasm to the mitochondria (Danio rerio)
Pink1 is recruited from the cytoplasm to the mitochondria (Gallus gallus)
Pink1 is recruited from the cytoplasm to the mitochondria (Mus musculus)
Pink1 is recruited from the cytoplasm to the mitochondria (Rattus norvegicus)
Pink1 is recruited from the cytoplasm to the mitochondria (Sus scrofa)
Authored
Gillespie, ME  (2013-11-21)
Reviewed
Chauss, D  (2015-09-01)
Kantorow, M  (2015-09-01)
Created
Gillespie, ME  (2013-12-05)
Cite Us!