Reactome | FZD2, FZD5 and ROR2 are internalized in a WNT5A and clathrin-dependent manner

Schema > BlackBoxEvent > Entries

FZD2, FZD5 and ROR2 are internalized in a WNT5A and clathrin-dependent manner Show undefined attributes

category	omitted
compartment	[Compartment:20592] clathrin-coated endocytic vesicle [Compartment:876] plasma membrane
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10285587
displayName	FZD2, FZD5 and ROR2 are internalized in a WNT5A and clathrin-dependent manner
eventOf	[Pathway:R-CFA-5140745] WNT5A-dependent internalization of FZD2, FZD5 and ROR2 - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[BlackBoxEvent:R-HSA-5140747] FZD2, FZD5 and ROR2 are internalized in a WNT5A and clathrin-dependent manner - Homo sapiens
input	[Complex:R-CFA-5140740] WNT5A:FZDs/ROR [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	FZD2, FZD5 and ROR2 are internalized in a WNT5A and clathrin-dependent manner
output	[Complex:R-CFA-5140748] WNT5A:FZDs/ROR [clathrin-coated endocytic vesicle membrane]
precedingEvent	[Reaction:R-CFA-5140741] WNT5A binds FZD and ROR receptors - Canis familiaris
regulatedBy	[Requirement:10285588] Requirement by 'clathrin:AP-2 [plasma membrane]'
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:49646] Canis familiaris
stId	R-CFA-5140747
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-5140745] WNT5A-dependent internalization of FZD2, FZD5 and ROR2
(inferredTo)	[BlackBoxEvent:R-HSA-5140747] FZD2, FZD5 and ROR2 are internalized in a WNT5A and clathrin-dependent manner

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