Reactome | FZD2, FZD5 and ROR2 are internalized in a WNT5A and clathrin-dependent manner

FZD2, FZD5 and ROR2 are internalized in a WNT5A and clathrin-dependent manner

Stable Identifier

R-HSA-5140747

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

clathrin-coated endocytic vesicle, plasma membrane

ReviewStatus

5/5

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FZD2, FZD5 and ROR2 are internalized in a WNT5A and clathrin-dependent manner

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Stimulation of HEK293, HeLaS3 or KKLS gastric cancer cells with WNT5A promotes the internalization of FZD2, FZD5 and ROR2. Internalization is required for RAC activation downstream of WNT5A and subsequent activation of laminin gamma 2 gene expression which is associated with metastasis and invasion in gastric cancer (Sato et al, 2010; Hanaki et al, 2012; Yamamoto et al, 2009). Knockdown or inhibition of clathrin abrogates receptor internalization and RAC activation suggesting that clathrin-mediated endocytosis is required for this WNT5A-dependent signaling (Sato et al, 2010; Hanaki et al, 2012).

Literature References

PubMed ID	Title	Journal	Year
19910923	Wnt5a regulates distinct signalling pathways by binding to Frizzled2 Sato, A, Yamamoto, H, Sakane, H, Koyama, H, Kikuchi, A	EMBO J.	2010
19582886	Laminin gamma2 mediates Wnt5a-induced invasion of gastric cancer cells Yamamoto, H, Yamamoto, H, Kitadai, Y, Oue, N, Ohdan, H, Yasui, W, Kikuchi, A	Gastroenterology	2009