FZD2, FZD5 and ROR2 are internalized in a WNT5A and clathrin-dependent manner

Stable Identifier
Reaction [BlackBoxEvent]
Homo sapiens
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Stimulation of HEK293, HeLaS3 or KKLS gastric cancer cells with WNT5A promotes the internalization of FZD2, FZD5 and ROR2. Internalization is required for RAC activation downstream of WNT5A and subsequent activation of laminin gamma 2 gene expression which is associated with metastasis and invasion in gastric cancer (Sato et al, 2010; Hanaki et al, 2012; Yamamoto et al, 2009). Knockdown or inhibition of clathrin abrogates receptor internalization and RAC activation suggesting that clathrin-mediated endocytosis is required for this WNT5A-dependent signaling (Sato et al, 2010; Hanaki et al, 2012).

Literature References
PubMed ID Title Journal Year
19910923 Wnt5a regulates distinct signalling pathways by binding to Frizzled2

Koyama, H, Kikuchi, A, Sato, A, Yamamoto, H, Sakane, H

EMBO J. 2010
19582886 Laminin gamma2 mediates Wnt5a-induced invasion of gastric cancer cells

Kikuchi, A, Kitadai, Y, Ohdan, H, Oue, N, Yasui, W, Yamamoto, H, Yamamoto, H

Gastroenterology 2009
This event is regulated
Orthologous Events
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