WNT5A binds FZD and ROR receptors

Stable Identifier
R-HSA-5140741
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane, extracellular region
ReviewStatus
5/5
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WNT5A binds FZD and ROR receptors
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WNT5A induces the internalization of FZD2, FZD5 and ROR2 in a clathrin-mediated route, but the activation of PKC is not required (Kurayoshi et al, 2007; Sato et al, 2010; Hanaki et al, 2012).
Literature References
PubMed ID Title Journal Year
19910923 Wnt5a regulates distinct signalling pathways by binding to Frizzled2

Koyama, H, Kikuchi, A, Sato, A, Yamamoto, H, Sakane, H

EMBO J. 2010
17117926 Post-translational palmitoylation and glycosylation of Wnt-5a are necessary for its signalling

Izumi, S, Kurayoshi, M, Kikuchi, A, Yamamoto, H

Biochem. J. 2007
22101459 An anti-Wnt5a antibody suppresses metastasis of gastric cancer cells in vivo by inhibiting receptor-mediated endocytosis

Kikuchi, A, Matsumoto, S, Sato, A, Ohdan, H, Hanaki, H, Yamamoto, H, Sakane, H

Mol. Cancer Ther. 2012
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Orthologous Events
WNT5A binds FZD and ROR receptors (Bos taurus)
WNT5A binds FZD and ROR receptors (Caenorhabditis elegans)
WNT5A binds FZD and ROR receptors (Canis familiaris)
WNT5A binds FZD and ROR receptors (Danio rerio)
WNT5A binds FZD and ROR receptors (Drosophila melanogaster)
WNT5A binds FZD and ROR receptors (Gallus gallus)
WNT5A binds FZD and ROR receptors (Mus musculus)
WNT5A binds FZD and ROR receptors (Rattus norvegicus)
WNT5A binds FZD and ROR receptors (Sus scrofa)
WNT5A binds FZD and ROR receptors (Xenopus tropicalis)
Authored
Kikuchi, A  (2013-11-13)
Created
Rothfels, K  (2013-11-15)
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