Reactome | WNT5A binds FZD and ROR receptors

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WNT5A binds FZD and ROR receptors Show undefined attributes

category	binding
compartment	[Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10875870
displayName	WNT5A binds FZD and ROR receptors
eventOf	[Pathway:R-DME-5140745] WNT5A-dependent internalization of FZD2, FZD5 and ROR2 - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-DME-5140747] FZD2, FZD5 and ROR2 are internalized in a WNT5A and clathrin-dependent manner - Drosophila melanogaster
inferredFrom	[Reaction:R-HSA-5140741] WNT5A binds FZD and ROR receptors - Homo sapiens
input	[CandidateSet:R-DME-5140732] FZD2/FZD5/ROR2 [plasma membrane] [EntityWithAccessionedSequence:R-DME-3247777] Wnt5 [extracellular region]
isInDisease	false
isInferred	true
maxDepth	1
name	WNT5A binds FZD and ROR receptors
output	[Complex:R-DME-5140740] WNT5A:FZDs/ROR [plasma membrane]
precedingEvent	[Reaction:R-DME-3247843] secretion of WNT ligands - Drosophila melanogaster
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-5140741
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-5140745] WNT5A-dependent internalization of FZD2, FZD5 and ROR2
(precedingEvent)	[BlackBoxEvent:R-DME-5140747] FZD2, FZD5 and ROR2 are internalized in a WNT5A and clathrin-dependent manner
(inferredTo)	[Reaction:R-HSA-5140741] WNT5A binds FZD and ROR receptors