Reactome | WNT5A binding to FZD promotes PRICKLE1 degradation

Schema > Reaction > Entries

WNT5A binding to FZD promotes PRICKLE1 degradation Show undefined attributes

authored	[InstanceEdit:5097382] Rothfels, K, 2013-11-11
category	binding
compartment	[Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:5099887] Rothfels, K, 2013-11-13
dbId	5099886
displayName	WNT5A binding to FZD promotes PRICKLE1 degradation
edited	[InstanceEdit:4663813] Matthews, L, 2013-10-07
eventOf	[Pathway:R-HSA-4608870] Asymmetric localization of PCP proteins - Homo sapiens
followingEvent	[Reaction:R-HSA-4608825] DVL2 is phosphorylated after WNT5A binding to FZD - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-3247777] N4GlycoAsn-PalmS WNT5A(36-380) [extracellular region] [CandidateSet:R-HSA-5140744] WNT5A-binding FZDs [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:4608829] Regulation of planar cell polarity by Smurf ubiquitin ligases
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	WNT5A binding to FZD promotes PRICKLE1 degradation
orthologousEvent	[Reaction:R-CEL-5099886] WNT5A binding to FZD promotes PRICKLE1 degradation - Caenorhabditis elegans [Reaction:R-DME-5099886] WNT5A binding to FZD promotes PRICKLE1 degradation - Drosophila melanogaster [Reaction:R-GGA-5099886] WNT5A binding to FZD promotes PRICKLE1 degradation - Gallus gallus [Reaction:R-XTR-5099886] WNT5A binding to FZD promotes PRICKLE1 degradation - Xenopus tropicalis [Reaction:R-DRE-5099886] WNT5A binding to FZD promotes PRICKLE1 degradation - Danio rerio [Reaction:R-SSC-5099886] WNT5A binding to FZD promotes PRICKLE1 degradation - Sus scrofa [Reaction:R-BTA-5099886] WNT5A binding to FZD promotes PRICKLE1 degradation - Bos taurus [Reaction:R-CFA-5099886] WNT5A binding to FZD promotes PRICKLE1 degradation - Canis familiaris [Reaction:R-RNO-5099886] WNT5A binding to FZD promotes PRICKLE1 degradation - Rattus norvegicus [Reaction:R-MMU-5099886] WNT5A binding to FZD promotes PRICKLE1 degradation - Mus musculus
output	[Complex:R-HSA-4608830] WNT5A:FZD [plasma membrane]
precedingEvent	[Reaction:R-HSA-3247843] secretion of WNT ligands - Homo sapiens
releaseDate	2013-12-04
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5099870] Kikuchi, Akira, 2013-11-12
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5099886
summation	[Summation:5099885] Binding of WNT5A to FZD receptors triggers the phosphorylati...

Referrals

(hasEvent)	[Pathway:R-HSA-4608870] Asymmetric localization of PCP proteins
(precedingEvent)	[Reaction:R-HSA-4608825] DVL2 is phosphorylated after WNT5A binding to FZD