WNT5A binding to FZD promotes PRICKLE1 degradation

Stable Identifier
R-HSA-5099886
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane, extracellular region
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
WNT5A binding to FZD promotes PRICKLE1 degradation
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Binding of WNT5A to FZD receptors triggers the phosphorylation of DVL2 in the constitutive DVL2:PARD6A complex and is required for the SMURF-mediated degradation of the core PCP protein PRICKLE1 (Narimatsu et al, 2009)

Literature References
PubMed ID Title Journal Year
19379695 Regulation of planar cell polarity by Smurf ubiquitin ligases

Narimatsu, M, Bose, R, Pye, M, Zhang, L, Miller, B, Ching, P, Sakuma, R, Luga, V, Roncari, L, Attisano, L, Wrana, JL

Cell 2009
Participants
Input
Output
Participant Of
hasEvent
Orthologous Events
WNT5A binding to FZD promotes PRICKLE1 degradation (Bos taurus)
WNT5A binding to FZD promotes PRICKLE1 degradation (Caenorhabditis elegans)
WNT5A binding to FZD promotes PRICKLE1 degradation (Canis familiaris)
WNT5A binding to FZD promotes PRICKLE1 degradation (Danio rerio)
WNT5A binding to FZD promotes PRICKLE1 degradation (Drosophila melanogaster)
WNT5A binding to FZD promotes PRICKLE1 degradation (Mus musculus)
WNT5A binding to FZD promotes PRICKLE1 degradation (Rattus norvegicus)
WNT5A binding to FZD promotes PRICKLE1 degradation (Sus scrofa)
Authored
Rothfels, K  (2013-11-12)
Reviewed
Kikuchi, A  (2013-11-13)
Created
Rothfels, K  (2013-11-13)
Cite Us!