WNT5A binding to FZD promotes PRICKLE1 degradation

Stable Identifier
R-HSA-5099886
Type
Reaction
Species
Homo sapiens
Compartment
plasma membrane, extracellular region
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WNT5A binding to FZD promotes PRICKLE1 degradation
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Binding of WNT5A to FZD receptors triggers the phosphorylation of DVL2 in the constitutive DVL2:PARD6A complex and is required for the SMURF-mediated degradation of the core PCP protein PRICKLE1 (Narimatsu et al, 2009)

Literature References
PubMed ID Title Journal Year
19379695 Regulation of planar cell polarity by Smurf ubiquitin ligases

Luga, V, Wrana, JL, Miller, B, Roncari, L, Sakuma, R, Bose, R, Ching, P, Attisano, L, Zhang, L, Pye, M, Narimatsu, M

Cell 2009
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Orthologous Events
WNT5A binding to FZD promotes PRICKLE1 degradation (Bos taurus)
WNT5A binding to FZD promotes PRICKLE1 degradation (Caenorhabditis elegans)
WNT5A binding to FZD promotes PRICKLE1 degradation (Canis familiaris)
WNT5A binding to FZD promotes PRICKLE1 degradation (Danio rerio)
WNT5A binding to FZD promotes PRICKLE1 degradation (Drosophila melanogaster)
WNT5A binding to FZD promotes PRICKLE1 degradation (Mus musculus)
WNT5A binding to FZD promotes PRICKLE1 degradation (Rattus norvegicus)
WNT5A binding to FZD promotes PRICKLE1 degradation (Sus scrofa)
WNT5A binding to FZD promotes PRICKLE1 degradation (Xenopus tropicalis)
Authored
Rothfels, K  (2013-11-11)
Reviewed
Kikuchi, A  (2013-11-12)
Created
Rothfels, K  (2013-11-13)
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