Reactome | a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1]

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a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] Show undefined attributes

authored	[InstanceEdit:517475] D'Eustachio, P, 2010-02-18
catalystActivity	[CatalystActivity:70700] branched-chain-amino-acid transaminase activity of BCAT1 dimer [cytosol]
catalystActivityReference	[CatalystActivityReference:9643740] branched-chain-amino-acid transaminase activity of BCAT1 dimer [cytosol] Structural determinants for branched-chain aminotransferase isozyme-specific inhibition by the anticonvulsant drug gabapentin
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:508183] D'Eustachio, P, 2010-02-10
crossReference	[DatabaseIdentifier:9917058] RHEA:18323 [DatabaseIdentifier:9917061] RHEA:24803 [DatabaseIdentifier:9917059] RHEA:24815
dbId	508189
displayName	a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1]
edited	[InstanceEdit:517475] D'Eustachio, P, 2010-02-18
eventOf	[Pathway:R-HSA-70895] Branched-chain amino acid catabolism - Homo sapiens
followingEvent	[Reaction:R-HSA-9672770] SLC25A44 transports Leu, Ile and Val from cytosol to mitochondrial matrix - Homo sapiens
input	[DefinedSet:R-ALL-508187] KIC,KMVA,KIV [cytosol] [SimpleEntity:R-ALL-29404] L-Glu [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:508185] Structural determinants for branched-chain aminotransferase isozyme-specific inhibition by the anticonvulsant drug gabapentin
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1]
negativePrecedingEvent	[NegativePrecedingEvent:9908872] Futile Cycle: leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1]
orthologousEvent	[Reaction:R-SCE-508189] a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] - Saccharomyces cerevisiae [Reaction:R-SPO-508189] a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] - Schizosaccharomyces pombe [Reaction:R-DDI-508189] a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] - Dictyostelium discoideum [Reaction:R-CEL-508189] a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] - Caenorhabditis elegans [Reaction:R-DME-508189] a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] - Drosophila melanogaster [Reaction:R-GGA-508189] a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] - Gallus gallus [Reaction:R-XTR-508189] a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] - Xenopus tropicalis [Reaction:R-DRE-508189] a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] - Danio rerio [Reaction:R-SSC-508189] a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] - Sus scrofa [Reaction:R-BTA-508189] a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] - Bos taurus [Reaction:R-CFA-508189] a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] - Canis familiaris [Reaction:R-RNO-508189] a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] - Rattus norvegicus [Reaction:R-MMU-508189] a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1] - Mus musculus
output	[SimpleEntity:R-ALL-29406] 2OG [cytosol] [DefinedSet:R-ALL-508182] Leu, Ile, Val [cytosol]
releaseDate	2010-03-16
reverseReaction	[Reaction:R-HSA-70723] leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1]
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:532425] Jassal, Bijay, 2010-02-26
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-508189
summation	[Summation:508231] Cytosolic branched-chain-amino-acid aminotransferase (BCAT1)...

Referrals

(hasEvent)	[Pathway:R-HSA-70895] Branched-chain amino acid catabolism
(precedingEvent)	[Reaction:R-HSA-9672770] SLC25A44 transports Leu, Ile and Val from cytosol to mitochondrial matrix [NegativePrecedingEvent:9908871] Futile Cycle: a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1]

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