Reactome | glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT]

Schema > Reaction > Entries

glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] Show undefined attributes

catalystActivity	[CatalystActivity:70653] ornithine-oxo-acid transaminase activity of OAT hexamer [mitochondrial matrix]
catalystActivityReference	[CatalystActivityReference:9643733] ornithine-oxo-acid transaminase activity of OAT hexamer [mitochondrial matrix] Crystallization and properties of human liver ornithine aminotransferase
category	transition
compartment	[Compartment:5460] mitochondrial matrix
crossReference	[DatabaseIdentifier:11881246] Rhea:25162
dbId	70666
displayName	glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT]
eventOf	[Pathway:R-HSA-8964539] Glutamate and glutamine metabolism - Homo sapiens
followingEvent	[Reaction:R-HSA-70560] carbamoyl phosphate + ornithine => citrulline + orthophosphate - Homo sapiens
input	[SimpleEntity:R-ALL-113552] L-Glu [mitochondrial matrix] [SimpleEntity:R-ALL-31339] L-Glu5S [mitochondrial matrix]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:70640] Ornithine delta-aminotransferase mutations in gyrate atrophy. Allelic heterogeneity and functional consequences. [Book:70631] The hyperornithinemias 0079130356 Scriver, Charles R The Metabolic and Molecular Bases of Inherited Disease, 8th ed
modified	[InstanceEdit:11879863] Wright, Adam, 2024-03-11
name	glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT]
orthologousEvent	[Reaction:R-PFA-70666] glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] - Plasmodium falciparum [Reaction:R-SCE-70666] glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] - Saccharomyces cerevisiae [Reaction:R-SPO-70666] glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] - Schizosaccharomyces pombe [Reaction:R-DDI-70666] glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] - Dictyostelium discoideum [Reaction:R-CEL-70666] glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] - Caenorhabditis elegans [Reaction:R-DME-70666] glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] - Drosophila melanogaster [Reaction:R-GGA-70666] glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] - Gallus gallus [Reaction:R-XTR-70666] glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] - Xenopus tropicalis [Reaction:R-SSC-70666] glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] - Sus scrofa [Reaction:R-BTA-70666] glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] - Bos taurus [Reaction:R-CFA-70666] glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] - Canis familiaris [Reaction:R-RNO-70666] glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] - Rattus norvegicus [Reaction:R-MMU-70666] glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT] - Mus musculus
output	[SimpleEntity:R-ALL-113594] 2OG [mitochondrial matrix] [SimpleEntity:R-ALL-113585] L-Orn [mitochondrial matrix]
precedingEvent	[Reaction:R-HSA-70667] 1PYR-5COOH spontaneously hydrolyses to L-GluSS - Homo sapiens
releaseDate	2004-07-06
reverseReaction	[Reaction:R-HSA-70654] ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT]
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-70666
summation	[Summation:178808] Mitochondrial ornithine aminotransferase (OAT) catalyzes the...

Referrals

(hasEvent)	[Pathway:R-HSA-8964539] Glutamate and glutamine metabolism
(precedingEvent)	[Reaction:R-HSA-70560] carbamoyl phosphate + ornithine => citrulline + orthophosphate

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