Transcriptional activation of CDKN1A by TP53 is inhibited by EP400

Stable Identifier
R-HSA-4647613
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Transcriptional activation of CDKN1A by TP53 is inhibited by EP400
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CDKN1A (p21) is transcriptionally activated by TP53 (p53) after DNA damage (el-Deiry et al. 1993). EP400 (p400) binds to a CDKN1A promoter region that overlaps with the distal TP53-binding site and can co-localize with TP53 on CDKN1A promoter. The presence of EP400 results in the downregulation of CDKN1A transcription without affecting the phosphorylation of TP53 on serine S15 (Chan et al. 2005).

Literature References
PubMed ID Title Journal Year
15655109 The p400 E1A-associated protein is a novel component of the p53 --> p21 senescence pathway

Livingston, DM, Lowe, SW, Narita, M, Chan, HM

Genes Dev. 2005
8242752 WAF1, a potential mediator of p53 tumor suppression.

Tokino, T, el-Deiry, WS, Kinzler, KW, Vogelstein, B, Lin, D, Mercer, WE, Parsons, R, Trent, JM, Velculescu, VE, Levy, DB

Cell 1993
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
EP400:p-S15-TP53 Tetramer:CDKN1A Gene [nucleoplasm] (Homo sapiens)
Active Unit
EP400 [nucleoplasm]
Positively by
Regulator
p-S15-TP53 Tetramer:CDKN1A Gene [nucleoplasm] (Homo sapiens)
Active Unit
p-S15-TP53 Tetramer [nucleoplasm]
Authored
Matthews, L  (2006-09-29)
Reviewed
Samarajiwa, S  (2013-09-03)
Created
Orlic-Milacic, M  (2013-09-30)
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