CDKN1A (p21) is transcriptionally activated by TP53 (p53) af...

created [InstanceEdit:4647599] Orlic-Milacic, M, 2013-09-30
dbId 4647602
displayName CDKN1A (p21) is transcriptionally activated by TP53 (p53) af...
schemaClass Summation
text CDKN1A (p21) is transcriptionally activated by TP53 (p53) after DNA damage (el-Deiry et al. 1993). EP400 (p400) binds to a CDKN1A promoter region that overlaps with the distal TP53-binding site and can co-localize with TP53 on CDKN1A promoter. The presence of EP400 results in the downregulation of CDKN1A transcription without affecting the phosphorylation of TP53 on serine S15 (Chan et al. 2005).
Cite Us!