Reactome | Asymmetric localization of PCP proteins

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Asymmetric localization of PCP proteins Show undefined attributes

compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10331091
displayName	Asymmetric localization of PCP proteins
eventOf	[Pathway:R-CFA-4086400] PCP/CE pathway - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-CFA-5099886] WNT5A binding to FZD promotes PRICKLE1 degradation - Canis familiaris [Reaction:R-CFA-4608854] SMURF1/2 are recruited to the DVL2:PARD6A complex - Canis familiaris [Reaction:R-CFA-4608852] SMURF1/2 ubiquitinates PRICKLE1 - Canis familiaris [BlackBoxEvent:R-CFA-4608855] PRICKLE1 is degraded by the proteasome - Canis familiaris
inferredFrom	[Pathway:R-HSA-4608870] Asymmetric localization of PCP proteins - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Asymmetric localization of PCP proteins
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:49646] Canis familiaris
stId	R-CFA-4608870
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-4086400] PCP/CE pathway
(inferredTo)	[Pathway:R-HSA-4608870] Asymmetric localization of PCP proteins

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