VANGL2 is phosphorylated in response to WNT5A

Stable Identifier
R-HSA-4551570
Type
Reaction [transition]
Species
Homo sapiens
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Based on studies in mouse, human VANGL2 is predicted to be phosphorylated and activated in response to WNT5A, possibly by CK1delta. Phosphorylation occurs on serine and threonine residues in 2 clusters and appears to be primed by phosphorylation at S5, S82 and S84. VANGL2 phosphorylation and activation occurs in a graded fashion in response to WNT5A distribution, helping to establish PCP asymmetry (Gao et al, 2011).

Literature References
PubMed ID Title Journal Year
21316585 Wnt signaling gradients establish planar cell polarity by inducing Vangl2 phosphorylation through Ror2

Gao, B, Song, H, Bishop, K, Elliot, G, Garrett, L, English, MA, Andre, P, Robinson, J, Sood, R, Minami, Y, Economides, AN, Yang, Y

Dev. Cell 2011
Participants
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hasEvent
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of unknown kinase [cytosol]
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Activity
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Created