Reactome | Transcription of POU5F1 (OCT4)

Schema > BlackBoxEvent > Entries

Transcription of POU5F1 (OCT4) Show undefined attributes

authored	[InstanceEdit:1013049] May, B, 2010-11-12
category	omitted
compartment	[Compartment:7660] nucleoplasm [Compartment:70101] cytosol
created	[InstanceEdit:452990] May, B, 2010-01-15
dbId	452392
displayName	Transcription of POU5F1 (OCT4)
edited	[InstanceEdit:1013049] May, B, 2010-11-12
eventOf	[Pathway:R-HSA-452723] Transcriptional regulation of pluripotent stem cells - Homo sapiens
followingEvent	[Reaction:R-HSA-500366] LIN28 binds POU5F1 (OCT4) mRNA - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-2888984] POU5F1 gene [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:452887] Oct4 expression in adult human stem cells: evidence in support of the stem cell theory of carcinogenesis [LiteratureReference:452879] Comparative transcriptional profiling of two human embryonic stem cell lines [LiteratureReference:452197] Reciprocal transcriptional regulation of Pou5f1 and Sox2 via the Oct4/Sox2 complex in embryonic stem cells [LiteratureReference:452318] Specific knockdown of Oct4 and beta2-microglobulin expression by RNA interference in human embryonic stem cells and embryonic carcinoma cells [LiteratureReference:452588] Stably transfected human embryonic stem cell clones express OCT4-specific green fluorescent protein and maintain self-renewal and pluripotency [LiteratureReference:453016] The transcriptome profile of human embryonic stem cells as defined by SAGE [LiteratureReference:452628] Analysis of Oct4-dependent transcriptional networks regulating self-renewal and pluripotency in human embryonic stem cells [LiteratureReference:452255] Induced pluripotent stem cell lines derived from human somatic cells [LiteratureReference:452538] Core transcriptional regulatory circuitry in human embryonic stem cells [LiteratureReference:453038] Characterization of human embryonic stem cell lines by the International Stem Cell Initiative [LiteratureReference:452756] A meta-analysis of human embryonic stem cells transcriptome integrated into a web-based expression atlas [LiteratureReference:452744] Characterization and gene expression profiling of five new human embryonic stem cell lines derived in Taiwan [LiteratureReference:480746] Reprogramming towards pluripotency requires AID-dependent DNA demethylation [LiteratureReference:480659] Hypoxia inducible factors regulate pluripotency and proliferation in human embryonic stem cells cultured at reduced oxygen tensions [LiteratureReference:500365] Lin28-mediated post-transcriptional regulation of Oct4 expression in human embryonic stem cells [LiteratureReference:994184] A novel SALL4/OCT4 transcriptional feedback network for pluripotency of embryonic stem cells [LiteratureReference:1101850] Oct-4 mRNA and protein expression during human preimplantation development [LiteratureReference:1059672] A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity [LiteratureReference:480737] Zfp206 is a transcription factor that controls pluripotency of embryonic stem cells [LiteratureReference:2972933] Silencing of core transcription factors in human EC cells highlights the importance of autocrine FGF signaling for self-renewal
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Transcription of POU5F1 (OCT4)
output	[EntityWithAccessionedSequence:R-HSA-500358] POU5F1 mRNA [cytosol]
precedingEvent	[Reaction:R-HSA-1112609] POU5F1 (OCT4), SOX2, NANOG, ZSCAN10, PRDM14, SMAD2, FOXP1-ES bind the POU5F1 (OCT4) promoter - Homo sapiens
regulatedBy	[PositiveGeneExpressionRegulation:R-HSA-453022] Positive gene expression regulation by 'NR5A1 [nucleoplasm]' [PositiveGeneExpressionRegulation:R-HSA-480862] Positive gene expression regulation by 'EPAS1 [nucleoplasm]' [PositiveGeneExpressionRegulation:R-HSA-5638452] Positive gene expression regulation by 'POU5F1:SOX2:NANOG:ZSCAN10:PRDM14:SMAD2:SALL4:FOXP1-ES:POU5F1 gene [nucleoplasm]'
regulationReference	[RegulationReference:9641472] Positive gene expression regulation by 'NR5A1 [nucleoplasm]' Transcriptional regulation of human Oct4 by steroidogenic factor-1 [RegulationReference:9642305] Positive gene expression regulation by 'POU5F1:SOX2:NANOG:ZSCAN10:PRDM14:SMAD2:SALL4:FOXP1-ES:POU5F1 gene [nucleoplasm]' Oct4 expression in adult human stem cells: evidence in support of the stem cell theory of carcinogenesis [RegulationReference:9642917] Positive gene expression regulation by 'EPAS1 [nucleoplasm]' Hypoxia inducible factors regulate pluripotency and proliferation in human embryonic stem cells cultured at reduced oxygen tensions
releaseDate	2014-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5246708] Wang, Jianlong, 2014-01-22
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-452392
summation	[Summation:500363] The POU5F1 (OCT4) gene is transcribed to yield mRNA and the ...
updateTrackers	[UpdateTracker:9785666] Update Tracker - [BlackBoxEvent:452392] Transcription of POU5F1 (OCT4) - v51:[addCatalystActivity, addRegulator, add_removeInput] [UpdateTracker:9778403] Update Tracker - [BlackBoxEvent:452392] Transcription of POU5F1 (OCT4) - v68:[removeCatalystActivity]

Referrals

(updatedInstance)	[UpdateTracker:9785666] Update Tracker - [BlackBoxEvent:452392] Transcription of POU5F1 (OCT4) - v51:[addCatalystActivity, addRegulator, add_removeInput] [UpdateTracker:9778403] Update Tracker - [BlackBoxEvent:452392] Transcription of POU5F1 (OCT4) - v68:[removeCatalystActivity]
(hasEvent)	[Pathway:R-HSA-452723] Transcriptional regulation of pluripotent stem cells
(precedingEvent)	[Reaction:R-HSA-500366] LIN28 binds POU5F1 (OCT4) mRNA

Cite Us!