Reactome | Silencing of core transcription factors in human EC cells highlights the importance of autocrine FGF signaling for self-renewal

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Silencing of core transcription factors in human EC cells highlights the importance of autocrine FGF signaling for self-renewal Show undefined attributes

author	[Person:2972927] Greber, B [Person:2972929] Lehrach, H [Person:2972924] Adjaye, J
created	[InstanceEdit:2972923] D'Eustachio, P, 2013-01-06
dbId	2972933
displayName	Silencing of core transcription factors in human EC cells highlights the importance of autocrine FGF signaling for self-renewal
journal	BMC Dev. Biol.
pages	46
pubMedIdentifier	17506876
schemaClass	LiteratureReference
title	Silencing of core transcription factors in human EC cells highlights the importance of autocrine FGF signaling for self-renewal
url	http://www.ncbi.nlm.nih.gov/pubmed/17506876
volume	7
year	2007

Referrals

(literatureReference)

[BlackBoxEvent:R-HSA-480509] Expression of EPHA1
[RegulationReference:9641629] Positive gene expression regulation by 'POU5F1:SOX2:NANOG:EPHA1 gene [nucleoplasm]' Analysis of Oct4-dependent transcriptional networks regulating self-renewal and pluripotency in human embryonic stem cells
[BlackBoxEvent:R-HSA-480470] Expression of ZIC3
[Reaction:R-HSA-2972978] POU5F1 (OCT4), SOX2, NANOG bind the ZIC3 promoter
[RegulationReference:9642290] Positive gene expression regulation by 'POU5F1:SOX2:NANOG:ZIC3 gene [nucleoplasm]' X-linked situs abnormalities result from mutations in ZIC3
[Reaction:R-HSA-2972967] POU5F1 (OCT4), SOX2, NANOG bind the EPHA1 promoter
[Reaction:R-HSA-2972965] POU5F1 (OCT4), SOX2, NANOG bind the TSC22D1 promoter
[Reaction:R-HSA-2972952] POU5F1 (OCT4), NANOG bind the GATA6 promoter
[BlackBoxEvent:R-HSA-452515] Expression of STAT3
[Reaction:R-HSA-2972956] POU5F1 (OCT4), SOX2, NANOG bind the STAT3 promoter
[RegulationReference:9642764] Positive gene expression regulation by 'POU5F1:SOX2:NANOG:STAT3 gene [nucleoplasm]' Regulation of self-renewal and pluripotency by Sox2 in human embryonic stem cells
[BlackBoxEvent:R-HSA-452338] Expression of TDGF1 (CRIPTO)
[Reaction:R-HSA-2972962] POU5F1 (OCT4), SOX2, NANOG bind the TDGF1 promoter
[RegulationReference:9641818] Positive gene expression regulation by 'POU5F1:SOX2:NANOG:TDGF1 gene [nucleoplasm]' Analysis of Oct4-dependent transcriptional networks regulating self-renewal and pluripotency in human embryonic stem cells
[BlackBoxEvent:R-HSA-480515] Expression of FGF2
[Reaction:R-HSA-2972960] POU5F1 (OCT4), SOX2, NANOG bind the FGF2 promoter
[BlackBoxEvent:R-HSA-452838] Expression of NANOG
[BlackBoxEvent:R-HSA-452392] Transcription of POU5F1 (OCT4)
[BlackBoxEvent:R-HSA-452894] Expression of SOX2
[RegulationReference:9641200] Positive gene expression regulation by 'POU5F1:SOX2:NANOG:SOX2 gene [nucleoplasm]' Comparative transcriptional profiling of two human embryonic stem cell lines
[RegulationReference:9642305] Positive gene expression regulation by 'POU5F1:SOX2:NANOG:ZSCAN10:PRDM14:SMAD2:SALL4:FOXP1-ES:POU5F1 gene [nucleoplasm]' Oct4 expression in adult human stem cells: evidence in support of the stem cell theory of carcinogenesis
[RegulationReference:9641771] Positive gene expression regulation by 'POU5F1:SOX2:NANOG:KLF4:PBX1:SMAD2:FOXP1-ES:NANOG gene [nucleoplasm]' Core transcriptional regulatory circuitry in human embryonic stem cells
[RegulationReference:9642288] Positive gene expression regulation by 'POU5F1:SOX2:NANOG:FGF2 gene [nucleoplasm]' Prevalent expression of fibroblast growth factor (FGF) receptors and FGF2 in human tumor cell lines

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