Reactome | Transcriptional regulation of pluripotent stem cells

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Transcriptional regulation of pluripotent stem cells Show undefined attributes

authored	[InstanceEdit:1013049] May, B, 2010-11-12
compartment	[Compartment:70101] cytosol [Compartment:7660] nucleoplasm
created	[InstanceEdit:452990] May, B, 2010-01-15
crossReference	[DatabaseIdentifier:12819675] BioModels Database:BIOMD0000000209 [DatabaseIdentifier:12819677] BioModels Database:BIOMD0000000210
dbId	452723
displayName	Transcriptional regulation of pluripotent stem cells
doi	10.3180/REACT_200812.1
edited	[InstanceEdit:1013049] May, B, 2010-11-12
eventOf	[TopLevelPathway:R-HSA-1266738] Developmental Biology - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:80100] somatic stem cell population maintenance
hasDiagram	true
hasEHLD	false
hasEvent	[BlackBoxEvent:R-HSA-480301] Expression of EPAS1 (HIF2A) - Homo sapiens [BlackBoxEvent:R-HSA-452392] Transcription of POU5F1 (OCT4) - Homo sapiens [Reaction:R-HSA-500366] LIN28 binds POU5F1 (OCT4) mRNA - Homo sapiens [BlackBoxEvent:R-HSA-2889036] Translation of OCT4 mRNA - Homo sapiens [BlackBoxEvent:R-HSA-452894] Expression of SOX2 - Homo sapiens [BlackBoxEvent:R-HSA-452838] Expression of NANOG - Homo sapiens [Reaction:R-HSA-480685] POU5F1 (OCT4), SOX2, NANOG bind the SOX2 promoter - Homo sapiens [Reaction:R-HSA-1112609] POU5F1 (OCT4), SOX2, NANOG, ZSCAN10, PRDM14, SMAD2, FOXP1-ES bind the POU5F1 (OCT4) promoter - Homo sapiens [Reaction:R-HSA-480204] POU5F1 (OCT4), SOX2, NANOG, KLF4, PBX1, SMAD2 bind the NANOG promoter - Homo sapiens [Reaction:R-HSA-2895778] POU5F1 (OCT4), STAT3 bind the SALL4 promoter - Homo sapiens [BlackBoxEvent:R-HSA-480520] Expression of SALL4 - Homo sapiens [Reaction:R-HSA-2972968] SALL4 binds the SALL4 promoter - Homo sapiens [Pathway:R-HSA-2892247] POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation - Homo sapiens [Pathway:R-HSA-2892245] POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2021-09-15
literatureReference	[LiteratureReference:452288] A gene expression signature shared by human mature oocytes and embryonic stem cells [LiteratureReference:452756] A meta-analysis of human embryonic stem cells transcriptome integrated into a web-based expression atlas [LiteratureReference:452628] Analysis of Oct4-dependent transcriptional networks regulating self-renewal and pluripotency in human embryonic stem cells [LiteratureReference:452744] Characterization and gene expression profiling of five new human embryonic stem cell lines derived in Taiwan [LiteratureReference:453038] Characterization of human embryonic stem cell lines by the International Stem Cell Initiative [LiteratureReference:452879] Comparative transcriptional profiling of two human embryonic stem cell lines [LiteratureReference:452993] Comparisons between transcriptional regulation and RNA expression in human embryonic stem cell lines [LiteratureReference:452538] Core transcriptional regulatory circuitry in human embryonic stem cells [LiteratureReference:453026] Differences between human and mouse embryonic stem cells [LiteratureReference:452878] Dissecting Oct3/4-regulated gene networks in embryonic stem cells by expression profiling [LiteratureReference:452287] Evolutionarily conserved transcriptional co-expression guiding embryonic stem cell differentiation [LiteratureReference:452948] In silico identification of a core regulatory network of OCT4 in human embryonic stem cells using an integrated approach [LiteratureReference:452255] Induced pluripotent stem cell lines derived from human somatic cells [LiteratureReference:452256] Induction of pluripotent stem cells from adult human fibroblasts by defined factors [LiteratureReference:452215] Profiling of differentially expressed genes in human stem cells by cDNA microarray [LiteratureReference:480659] Hypoxia inducible factors regulate pluripotency and proliferation in human embryonic stem cells cultured at reduced oxygen tensions [LiteratureReference:480746] Reprogramming towards pluripotency requires AID-dependent DNA demethylation [LiteratureReference:2901797] Accessing na�ve human pluripotency [LiteratureReference:2901803] Network of WNT and other regulatory signaling cascades in pluripotent stem cells and cancer stem cells [LiteratureReference:452533] Crystal structure of a POU/HMG/DNA ternary complex suggests differential assembly of Oct4 and Sox2 on two enhancers [LiteratureReference:2975845] DNA-dependent Oct4-Sox2 interaction and diffusion properties characteristic of the pluripotent cell state revealed by fluorescence spectroscopy [LiteratureReference:3006304] Pluripotency and nuclear reprogramming [LiteratureReference:3319459] Characterization of pluripotent stem cells [LiteratureReference:3319434] The architectural organization of human stem cell cycle regulatory machinery [LiteratureReference:3319436] Transcriptional control of embryonic and induced pluripotent stem cells [LiteratureReference:3319456] Conserved and divergent roles of FGF signaling in mouse epiblast stem cells and human embryonic stem cells [LiteratureReference:3319465] Embryonic stem cells and inducible pluripotent stem cells: two faces of the same coin? [LiteratureReference:3903033] Regulation of stem cell pluripotency and differentiation involves a mutual regulatory circuit of the NANOG, OCT4, and SOX2 pluripotency transcription factors with polycomb repressive complexes and stem cell microRNAs [LiteratureReference:5185713] Reprogramming DNA methylation in the mammalian life cycle: building and breaking epigenetic barriers [LiteratureReference:5244457] A protein interaction network for pluripotency of embryonic stem cells [LiteratureReference:5244481] Oct4 links multiple epigenetic pathways to the pluripotency network [LiteratureReference:5159201] Modeling co-expression across species for complex traits: insights to the difference of human and mouse embryonic stem cells
maxDepth	3
modified	[InstanceEdit:9847082] Weiser, Joel, 2023-10-12
name	Transcriptional regulation of pluripotent stem cells
releaseDate	2014-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5246708] Wang, Jianlong, 2014-01-22
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-452723
summation	[Summation:500359] Pluripotent stem cells are undifferentiated cells posessing ...
updateTrackers	[UpdateTracker:9782381] Update Tracker - [Pathway:452723] Transcriptional regulation of pluripotent stem cells - v59:[updateContainedRLE] [UpdateTracker:9775857] Update Tracker - [Pathway:452723] Transcriptional regulation of pluripotent stem cells - v78:[updateContainedRLE] [UpdateTracker:9778523] Update Tracker - [Pathway:452723] Transcriptional regulation of pluripotent stem cells - v68:[updateContainedRLE] [UpdateTracker:9783972] Update Tracker - [Pathway:452723] Transcriptional regulation of pluripotent stem cells - v55:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9778859] Update Tracker - [Pathway:452723] Transcriptional regulation of pluripotent stem cells - v67:[updateContainedRLE] [UpdateTracker:9785694] Update Tracker - [Pathway:452723] Transcriptional regulation of pluripotent stem cells - v51:[updateContainedRLE, updateIndirectRLE]

Referrals

(hasEvent)

[TopLevelPathway:R-HSA-1266738] Developmental Biology

(updatedInstance)

[UpdateTracker:9782381] Update Tracker - [Pathway:452723] Transcriptional regulation of pluripotent stem cells - v59:[updateContainedRLE]
[UpdateTracker:9775857] Update Tracker - [Pathway:452723] Transcriptional regulation of pluripotent stem cells - v78:[updateContainedRLE]
[UpdateTracker:9778523] Update Tracker - [Pathway:452723] Transcriptional regulation of pluripotent stem cells - v68:[updateContainedRLE]
[UpdateTracker:9783972] Update Tracker - [Pathway:452723] Transcriptional regulation of pluripotent stem cells - v55:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9778859] Update Tracker - [Pathway:452723] Transcriptional regulation of pluripotent stem cells - v67:[updateContainedRLE]
[UpdateTracker:9785694] Update Tracker - [Pathway:452723] Transcriptional regulation of pluripotent stem cells - v51:[updateContainedRLE, updateIndirectRLE]

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