Reactome | LIN28 binds POU5F1 (OCT4) mRNA

Schema > Reaction > Entries

authored	[InstanceEdit:1013049] May, B, 2010-11-12
category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:500370] May, B, 2010-02-03
dbId	500366
displayName	LIN28 binds POU5F1 (OCT4) mRNA
edited	[InstanceEdit:1013049] May, B, 2010-11-12
eventOf	[Pathway:R-HSA-452723] Transcriptional regulation of pluripotent stem cells - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-2889036] Translation of OCT4 mRNA - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-500391] LIN28A [cytosol] [EntityWithAccessionedSequence:R-HSA-500358] POU5F1 mRNA [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:500365] Lin28-mediated post-transcriptional regulation of Oct4 expression in human embryonic stem cells [LiteratureReference:2888921] Determinants of mRNA recognition and translation regulation by Lin28
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	LIN28 binds POU5F1 (OCT4) mRNA
output	[Complex:R-HSA-500373] LIN28:POU5F1 mRNA [cytosol]
precedingEvent	[BlackBoxEvent:R-HSA-452392] Transcription of POU5F1 (OCT4) - Homo sapiens
releaseDate	2014-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5246708] Wang, Jianlong, 2014-01-22
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-500366
summation	[Summation:500357] LIN28 binds the R2 region of the POU5F1 (OCT4) mRNA and incr...

(hasEvent)	[Pathway:R-HSA-452723] Transcriptional regulation of pluripotent stem cells
(precedingEvent)	[BlackBoxEvent:R-HSA-2889036] Translation of OCT4 mRNA

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