Reactome | AUF1 (hnRNP D0) is ubiquitinylated

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AUF1 (hnRNP D0) is ubiquitinylated Show undefined attributes

authored	[InstanceEdit:451187] May, B, 2009-12-29
category	omitted
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:450588] May, B, 2009-12-16
dbId	450580
displayName	AUF1 (hnRNP D0) is ubiquitinylated
edited	[InstanceEdit:451187] May, B, 2009-12-29
eventOf	[Pathway:R-HSA-450408] AUF1 (hnRNP D0) binds and destabilizes mRNA - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-450466] AUF1:mRNA complex is degraded - Homo sapiens
input	[Complex:R-HSA-450623] AUF1 Complexed with Translation and Heat Shock Proteins [cytosol] 4 × [DefinedSet:R-HSA-113595] Ub [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:450572] Alternate exon insertion controls selective ubiquitination and degradation of different AUF1 protein isoforms [LiteratureReference:450421] Control of mRNA decay by heat shock-ubiquitin-proteasome pathway [LiteratureReference:450528] Ubiquitin-dependent mechanism regulates rapid turnover of AU-rich cytokine mRNAs [LiteratureReference:450367] Assembly of AUF1 oligomers on U-rich RNA targets by sequential dimer association
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	AUF1 (hnRNP D0) is ubiquitinylated
orthologousEvent	[BlackBoxEvent:R-PFA-450580] AUF1 (hnRNP D0) is ubiquitinylated - Plasmodium falciparum [BlackBoxEvent:R-DDI-450580] AUF1 (hnRNP D0) is ubiquitinylated - Dictyostelium discoideum [BlackBoxEvent:R-DME-450580] AUF1 (hnRNP D0) is ubiquitinylated - Drosophila melanogaster [BlackBoxEvent:R-GGA-450580] AUF1 (hnRNP D0) is ubiquitinylated - Gallus gallus [BlackBoxEvent:R-XTR-450580] AUF1 (hnRNP D0) is ubiquitinylated - Xenopus tropicalis [BlackBoxEvent:R-DRE-450580] AUF1 (hnRNP D0) is ubiquitinylated - Danio rerio [BlackBoxEvent:R-SSC-450580] AUF1 (hnRNP D0) is ubiquitinylated - Sus scrofa [BlackBoxEvent:R-BTA-450580] AUF1 (hnRNP D0) is ubiquitinylated - Bos taurus [BlackBoxEvent:R-CFA-450580] AUF1 (hnRNP D0) is ubiquitinylated - Canis familiaris [BlackBoxEvent:R-RNO-450580] AUF1 (hnRNP D0) is ubiquitinylated - Rattus norvegicus [BlackBoxEvent:R-MMU-450580] AUF1 (hnRNP D0) is ubiquitinylated - Mus musculus
output	[Complex:R-HSA-450458] Ubiquitinated AUF1 Tetramer: Destabilized mRNA Complex [cytosol]
precedingEvent	[Reaction:R-HSA-450551] AUF1 binds translation and heat shock proteins - Homo sapiens
releaseDate	2010-09-21
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:882027] Wilusz, J, 2010-06-29
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-450580
summation	[Summation:451185] AUF1 is ubiquitinated at unknown sites. The number of ubiqui...

Referrals

(precedingEvent)	[BlackBoxEvent:R-HSA-450466] AUF1:mRNA complex is degraded
(hasEvent)	[Pathway:R-HSA-450408] AUF1 (hnRNP D0) binds and destabilizes mRNA