AUF1 (hnRNP D0) is ubiquitinylated

Stable Identifier
Reaction [BlackBoxEvent]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

AUF1 is ubiquitinated at unknown sites. The number of ubiquitin molecules conjugated to AUF1 and their linkage is unknown. Ubiquitination is required for subsequent degradation of both AUF1 and the mRNA bound by AUF1. It is uncertain if AUF1 is in a larger complex when it is ubiquitinated.

Literature References
PubMed ID Title Journal Year
12136087 Alternate exon insertion controls selective ubiquitination and degradation of different AUF1 protein isoforms

Schneider, RJ, Laroia, G

Nucleic Acids Res 2002
10559216 Assembly of AUF1 oligomers on U-rich RNA targets by sequential dimer association

Brewer, G, Wilson, GM, Lu, H, Sun, Y

J Biol Chem 1999
11842200 Ubiquitin-dependent mechanism regulates rapid turnover of AU-rich cytokine mRNAs

Schneider, RJ, Laroia, G, Sarkar, B

Proc Natl Acad Sci U S A 2002
10205060 Control of mRNA decay by heat shock-ubiquitin-proteasome pathway

Brewer, G, Schneider, RJ, Laroia, G, Cuesta, R

Science 1999
Orthologous Events
Cite Us!