Reactome | AUF1 (hnRNP D0) is ubiquitinylated

AUF1 (hnRNP D0) is ubiquitinylated

Stable Identifier

R-HSA-450580

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

AUF1 is ubiquitinated at unknown sites. The number of ubiquitin molecules conjugated to AUF1 and their linkage is unknown. Ubiquitination is required for subsequent degradation of both AUF1 and the mRNA bound by AUF1. It is uncertain if AUF1 is in a larger complex when it is ubiquitinated.

Literature References

PubMed ID	Title	Journal	Year
12136087	Alternate exon insertion controls selective ubiquitination and degradation of different AUF1 protein isoforms Schneider, RJ, Laroia, G	Nucleic Acids Res	2002
10559216	Assembly of AUF1 oligomers on U-rich RNA targets by sequential dimer association Brewer, G, Wilson, GM, Lu, H, Sun, Y	J Biol Chem	1999
11842200	Ubiquitin-dependent mechanism regulates rapid turnover of AU-rich cytokine mRNAs Schneider, RJ, Laroia, G, Sarkar, B	Proc Natl Acad Sci U S A	2002
10205060	Control of mRNA decay by heat shock-ubiquitin-proteasome pathway Brewer, G, Schneider, RJ, Laroia, G, Cuesta, R	Science	1999