Reactome | AUF1 (hnRNP D0) binds and destabilizes mRNA

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AUF1 (hnRNP D0) binds and destabilizes mRNA Show undefined attributes

authored	[InstanceEdit:451187] May, B, 2009-12-29
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:450588] May, B, 2009-12-16
dbId	450408
displayName	AUF1 (hnRNP D0) binds and destabilizes mRNA
edited	[InstanceEdit:451187] May, B, 2009-12-29
eventOf	[Pathway:R-HSA-450531] Regulation of mRNA stability by proteins that bind AU-rich elements - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:171831] regulation of mRNA stability
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-450434] AUF1(hnRNP D0) dimers bind AU-rich element in 3' UTR of mRNA - Homo sapiens [Reaction:R-HSA-450551] AUF1 binds translation and heat shock proteins - Homo sapiens [BlackBoxEvent:R-HSA-450580] AUF1 (hnRNP D0) is ubiquitinylated - Homo sapiens [BlackBoxEvent:R-HSA-450466] AUF1:mRNA complex is destroyed - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:450487] Chaperone Hsp27, a novel subunit of AUF1 protein complexes, functions in AU-rich element-mediated mRNA decay [LiteratureReference:450615] Regulation of A + U-rich element-directed mRNA turnover involving reversible phosphorylation of AUF1 [LiteratureReference:450421] Control of mRNA decay by heat shock-ubiquitin-proteasome pathway [LiteratureReference:451092] AU-rich element-mediated translational control: complexity and multiple activities of trans-activating factors [LiteratureReference:451135] AU-rich elements and associated factors: are there unifying principles? [LiteratureReference:451157] Post-transcriptional regulation of gene expression by degradation of messenger RNAs
modified	[InstanceEdit:10931649] Wright, Adam, 2024-03-08
name	AUF1 (hnRNP D0) binds and destabilizes mRNA
orthologousEvent	[Pathway:R-PFA-450408] AUF1 (hnRNP D0) binds and destabilizes mRNA - Plasmodium falciparum [Pathway:R-DDI-450408] AUF1 (hnRNP D0) binds and destabilizes mRNA - Dictyostelium discoideum [Pathway:R-DME-450408] AUF1 (hnRNP D0) binds and destabilizes mRNA - Drosophila melanogaster [Pathway:R-GGA-450408] AUF1 (hnRNP D0) binds and destabilizes mRNA - Gallus gallus [Pathway:R-XTR-450408] AUF1 (hnRNP D0) binds and destabilizes mRNA - Xenopus tropicalis [Pathway:R-DRE-450408] AUF1 (hnRNP D0) binds and destabilizes mRNA - Danio rerio [Pathway:R-SSC-450408] AUF1 (hnRNP D0) binds and destabilizes mRNA - Sus scrofa [Pathway:R-BTA-450408] AUF1 (hnRNP D0) binds and destabilizes mRNA - Bos taurus [Pathway:R-CFA-450408] AUF1 (hnRNP D0) binds and destabilizes mRNA - Canis familiaris [Pathway:R-RNO-450408] AUF1 (hnRNP D0) binds and destabilizes mRNA - Rattus norvegicus [Pathway:R-MMU-450408] AUF1 (hnRNP D0) binds and destabilizes mRNA - Mus musculus
releaseDate	2010-09-21
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:882027] Wilusz, J, 2010-06-29
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-450408
summation	[Summation:451163] AUF1 (hnRNP D0) dimers bind U-rich regions of AU-rich elemen...

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[Pathway:R-HSA-450531] Regulation of mRNA stability by proteins that bind AU-rich elements

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