Reactome | ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1

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ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1 Show undefined attributes

authored	[InstanceEdit:749521] Dall'Olio, GM, 2009-11-10
catalystActivity	[CatalystActivity:449367] mannosyltransferase activity of ALG12 [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:17957] endoplasmic reticulum lumen
created	[InstanceEdit:446206] Jassal, B, 2009-11-10
dbId	446198
diseaseReaction	[FailedReaction:R-HSA-4686998] Defective MPDU1 does not promote transfer of Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1 by ALG12 - Homo sapiens [FailedReaction:R-HSA-4720497] Defective ALG12 does not add mannose to the N-glycan precursor - Homo sapiens
displayName	ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1
edited	[InstanceEdit:446206] Jassal, B, 2009-11-10
eventOf	[Pathway:R-HSA-446193] Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein - Homo sapiens
figure	[Figure:975566] /figures/11_GlcNAc2Man8PPDol.png
followingEvent	[Reaction:R-HSA-446216] ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)8 (PP-Dol)1 - Homo sapiens
input	[SimpleEntity:R-ALL-449312] (GlcNAc)2 (Man)7 (PP-Dol)1 [lumenal side of endoplasmic reticulum membrane] [SimpleEntity:R-ALL-449229] DOLP-Man [lumenal side of endoplasmic reticulum membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:449352] Congenital disorders of glycosylation type Ig is defined by a deficiency in dolichyl-P-mannose:Man7GlcNAc2-PP-dolichyl mannosyltransferase
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1 Addition of the eighth mannose to the N-glycan precursor by ALG12
orthologousEvent	[Reaction:R-SCE-446198] ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1 - Saccharomyces cerevisiae [Reaction:R-SPO-446198] ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1 - Schizosaccharomyces pombe [Reaction:R-DDI-446198] ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1 - Dictyostelium discoideum [Reaction:R-CEL-446198] ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1 - Caenorhabditis elegans [Reaction:R-DME-446198] ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1 - Drosophila melanogaster [Reaction:R-GGA-446198] ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1 - Gallus gallus [Reaction:R-XTR-446198] ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1 - Xenopus tropicalis [Reaction:R-DRE-446198] ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1 - Danio rerio [Reaction:R-SSC-446198] ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1 - Sus scrofa [Reaction:R-BTA-446198] ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1 - Bos taurus [Reaction:R-CFA-446198] ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1 - Canis familiaris [Reaction:R-RNO-446198] ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1 - Rattus norvegicus [Reaction:R-MMU-446198] ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1 - Mus musculus
output	[SimpleEntity:R-ALL-449365] (GlcNAc)2 (Man)8 (PP-Dol)1 [lumenal side of endoplasmic reticulum membrane] [SimpleEntity:R-ALL-449311] DOLP [lumenal side of endoplasmic reticulum membrane]
precedingEvent	[Reaction:R-HSA-446215] ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)6 (PP-Dol)1 - Homo sapiens
regulatedBy	[PositiveRegulation:R-HSA-4628426] Positive regulation by 'MPDU1 [endoplasmic reticulum membrane]'
releaseDate	2010-06-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:749519] Gagneux, P, 2010-04-16
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-446198
summation	[Summation:449364] The eighth mannose is added to the N-glycan precursor. This ...
updateTrackers	[UpdateTracker:9786892] Update Tracker - [Reaction:446198] ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1 - v47:[addRegulator] [UpdateTracker:9790318] Update Tracker - [Reaction:446198] ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1 - v34:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9786892] Update Tracker - [Reaction:446198] ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1 - v47:[addRegulator] [UpdateTracker:9790318] Update Tracker - [Reaction:446198] ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1 - v34:[modifyText]
(normalReaction)	[FailedReaction:R-HSA-4686998] Defective MPDU1 does not promote transfer of Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1 by ALG12 [FailedReaction:R-HSA-4720497] Defective ALG12 does not add mannose to the N-glycan precursor
(hasEvent)	[Pathway:R-HSA-446193] Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
(precedingEvent)	[Reaction:R-HSA-446216] ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)8 (PP-Dol)1

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