ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1

Stable Identifier
R-HSA-446198
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
Addition of the eighth mannose to the N-glycan precursor by ALG12
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The eighth mannose is added to the N-glycan precursor. This reaction occurs in the ER lumen and uses dolichyl phosphate D-mannose as a mannose donor. Defects in ALG12 are the cause of congenital disorder of glycosylation type 1G (CDG1G) (Chantret I et al, 2002).

Literature References
PubMed ID Title Journal Year
11983712 Congenital disorders of glycosylation type Ig is defined by a deficiency in dolichyl-P-mannose:Man7GlcNAc2-PP-dolichyl mannosyltransferase

Chantret, I, Dupré, T, Delenda, C, Bucher, S, Dancourt, J, Barnier, A, Charollais, A, Heron, D, Bader-Meunier, B, Danos, O, Seta, N, Durand, G, Oriol, R, Codogno, P, Moore, SE

J Biol Chem 2002
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
mannosyltransferase activity of ALG12 [endoplasmic reticulum membrane]
Physical Entity
Activity
This event is regulated
Orthologous Events
Authored
Reviewed
Created