The eighth mannose is added to the N-glycan precursor. This reaction occurs in the ER lumen and uses dolichyl phosphate D-mannose as a mannose donor. Defects in ALG12 are the cause of congenital disorder of glycosylation type 1G (CDG1G) (Chantret I et al, 2002).
Dupré, T, Danos, O, Chantret, I, Bader-Meunier, B, Seta, N, Bucher, S, Barnier, A, Heron, D, Durand, G, Codogno, P, Oriol, R, Moore, SE, Delenda, C, Charollais, A, Dancourt, J
mannosyltransferase activity of ALG12 [endoplasmic reticulum membrane]
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