Reactome | ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1

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ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1 Show undefined attributes

catalystActivity	[CatalystActivity:10479605] mannosyltransferase activity of ALG12 [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:17957] endoplasmic reticulum lumen
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10479607
displayName	ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1
eventOf	[Pathway:R-SSC-446193] Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SSC-446216] ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)8 (PP-Dol)1 - Sus scrofa
inferredFrom	[Reaction:R-HSA-446198] ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1 - Homo sapiens
input	[SimpleEntity:R-ALL-449312] (GlcNAc)2 (Man)7 (PP-Dol)1 [lumenal side of endoplasmic reticulum membrane] [SimpleEntity:R-ALL-449229] DOLP-Man [lumenal side of endoplasmic reticulum membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1 Addition of the eighth mannose to the N-glycan precursor by ALG12
output	[SimpleEntity:R-ALL-449365] (GlcNAc)2 (Man)8 (PP-Dol)1 [lumenal side of endoplasmic reticulum membrane] [SimpleEntity:R-ALL-449311] DOLP [lumenal side of endoplasmic reticulum membrane]
precedingEvent	[Reaction:R-SSC-446215] ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)6 (PP-Dol)1 - Sus scrofa
regulatedBy	[PositiveRegulation:10479579] Positive regulation by 'MPDU1 [endoplasmic reticulum membrane]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-446198
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-446193] Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
(precedingEvent)	[Reaction:R-SSC-446216] ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)8 (PP-Dol)1
(inferredTo)	[Reaction:R-HSA-446198] ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1

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