Reactome | ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)6 (PP-Dol)1

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ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)6 (PP-Dol)1 Show undefined attributes

authored	[InstanceEdit:749521] Dall'Olio, GM, 2009-11-10
catalystActivity	[CatalystActivity:449260] alpha-1,2-mannosyltransferase activity of ALG9 [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:17957] endoplasmic reticulum lumen
created	[InstanceEdit:446206] Jassal, B, 2009-11-10
dbId	446215
diseaseReaction	[FailedReaction:R-HSA-9036021] Defective MPDU1 does not promote transfer of Man to (GlcNAc)2 (Man)6 (PP-Dol)1 by ALG9 - Homo sapiens [FailedReaction:R-HSA-4720478] Defective ALG9 does not add the seventh mannose to the N-glycan precursor - Homo sapiens
displayName	ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)6 (PP-Dol)1
edited	[InstanceEdit:446206] Jassal, B, 2009-11-10
eventOf	[Pathway:R-HSA-446193] Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein - Homo sapiens
figure	[Figure:975570] /figures/10_GlcNAc2Man7PPDol.png
followingEvent	[Reaction:R-HSA-446198] ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1 - Homo sapiens
input	[SimpleEntity:R-ALL-449315] (GlcNAc)2 (Man)6 (PP-Dol)1 [lumenal side of endoplasmic reticulum membrane] [SimpleEntity:R-ALL-449229] DOLP-Man [lumenal side of endoplasmic reticulum membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:449309] A mannosyltransferase gene at 11q23 is disrupted by a translocation breakpoint that co-segregates with bipolar affective disorder in a small family [LiteratureReference:449278] Common variations in ALG9 are not associated with bipolar I disorder: a family-based study [LiteratureReference:449292] Identification and functional analysis of a defect in the human ALG9 gene: definition of congenital disorder of glycosylation type IL [LiteratureReference:449280] CDG-IL: an infant with a novel mutation in the ALG9 gene and additional phenotypic features
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)6 (PP-Dol)1 Addition of the seventh mannose to the N-glycan precursor by ALG9
orthologousEvent	[Reaction:R-SCE-446215] ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)6 (PP-Dol)1 - Saccharomyces cerevisiae [Reaction:R-SPO-446215] ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)6 (PP-Dol)1 - Schizosaccharomyces pombe [Reaction:R-DDI-446215] ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)6 (PP-Dol)1 - Dictyostelium discoideum [Reaction:R-CEL-446215] ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)6 (PP-Dol)1 - Caenorhabditis elegans [Reaction:R-DME-446215] ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)6 (PP-Dol)1 - Drosophila melanogaster [Reaction:R-GGA-446215] ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)6 (PP-Dol)1 - Gallus gallus [Reaction:R-XTR-446215] ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)6 (PP-Dol)1 - Xenopus tropicalis [Reaction:R-SSC-446215] ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)6 (PP-Dol)1 - Sus scrofa [Reaction:R-BTA-446215] ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)6 (PP-Dol)1 - Bos taurus [Reaction:R-CFA-446215] ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)6 (PP-Dol)1 - Canis familiaris [Reaction:R-RNO-446215] ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)6 (PP-Dol)1 - Rattus norvegicus [Reaction:R-MMU-446215] ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)6 (PP-Dol)1 - Mus musculus
output	[SimpleEntity:R-ALL-449312] (GlcNAc)2 (Man)7 (PP-Dol)1 [lumenal side of endoplasmic reticulum membrane] [SimpleEntity:R-ALL-449311] DOLP [lumenal side of endoplasmic reticulum membrane]
precedingEvent	[Reaction:R-HSA-446188] ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1 - Homo sapiens
regulatedBy	[PositiveRegulation:R-HSA-4628425] Positive regulation by 'MPDU1 [endoplasmic reticulum membrane]'
releaseDate	2010-06-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:749519] Gagneux, P, 2010-04-16
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-446215
summation	[Summation:449285] The seventh mannose is added to the N-glycan precursor. This...
updateTrackers	[UpdateTracker:9790315] Update Tracker - [Reaction:446215] ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)6 (PP-Dol)1 - v34:[modifyText] [UpdateTracker:9786952] Update Tracker - [Reaction:446215] ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)6 (PP-Dol)1 - v47:[addRegulator]

Referrals

(updatedInstance)	[UpdateTracker:9790315] Update Tracker - [Reaction:446215] ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)6 (PP-Dol)1 - v34:[modifyText] [UpdateTracker:9786952] Update Tracker - [Reaction:446215] ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)6 (PP-Dol)1 - v47:[addRegulator]
(normalReaction)	[FailedReaction:R-HSA-9036021] Defective MPDU1 does not promote transfer of Man to (GlcNAc)2 (Man)6 (PP-Dol)1 by ALG9 [FailedReaction:R-HSA-4720478] Defective ALG9 does not add the seventh mannose to the N-glycan precursor
(precedingEvent)	[Reaction:R-HSA-446198] ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1
(hasEvent)	[Pathway:R-HSA-446193] Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein

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