Reactome | ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1

Schema > Reaction > Entries

ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1 Show undefined attributes

catalystActivity	[CatalystActivity:10444531] mannosyltransferase activity of ALG12 [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:17957] endoplasmic reticulum lumen
created	[InstanceEdit:10427439] Wright, Adam, 2024-03-07
dbId	10444533
displayName	ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1
eventOf	[Pathway:R-DRE-446193] Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein - Danio rerio
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-446198] ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1 - Homo sapiens
input	[SimpleEntity:R-ALL-449312] (GlcNAc)2 (Man)7 (PP-Dol)1 [integral component of lumenal side of endoplasmic reticulum membrane] [SimpleEntity:R-ALL-449229] DOLP-Man [integral component of lumenal side of endoplasmic reticulum membrane]
isInDisease	false
isInferred	true
name	ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1 Addition of the eighth mannose to the N-glycan precursor by ALG12
output	[SimpleEntity:R-ALL-449365] (GlcNAc)2 (Man)8 (PP-Dol)1 [integral component of lumenal side of endoplasmic reticulum membrane] [SimpleEntity:R-ALL-449311] DOLP [integral component of lumenal side of endoplasmic reticulum membrane]
regulatedBy	[PositiveRegulation:10444505] Positive regulation by 'MPDU1 [endoplasmic reticulum membrane]'
releaseDate	2024-03-27
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-446198
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-446193] Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
(inferredTo)	[Reaction:R-HSA-446198] ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1