Reactome | Signal transduction by L1

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Signal transduction by L1 Show undefined attributes

authored	[InstanceEdit:374671] Garapati, P V, 2008-07-30 10:22:58
created	[InstanceEdit:445142] Garapati, P V, 2009-10-27
dbId	445144
displayName	Signal transduction by L1
edited	[InstanceEdit:374671] Garapati, P V, 2008-07-30 10:22:58
eventOf	[Pathway:R-HSA-373760] L1CAM interactions - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-374681] L1 and NCAM1 engaged in cis-interaction - Homo sapiens [Reaction:R-HSA-437230] L1-FGFR cis-heterodimerization - Homo sapiens [Reaction:R-HSA-445069] L1-EGFR trans-heterodimerization - Homo sapiens [Reaction:R-HSA-374669] L1 binds NRP1 - Homo sapiens [Reaction:R-HSA-374686] L1 interaction with Integrins - Homo sapiens [BlackBoxEvent:R-HSA-445085] Phosphorylation of VAV2 - Homo sapiens [Reaction:R-HSA-445064] Activation of Rac1 by VAV2 - Homo sapiens [Reaction:R-HSA-445072] Interaction of PAK1 with Rac1-GTP - Homo sapiens [Reaction:R-HSA-109860] MAP2K1 phosphorylates MAPK3 - Homo sapiens [Reaction:R-HSA-109862] MAP2K2 phosphorylates MAPK1 - Homo sapiens [Reaction:R-HSA-392752] Phosphorylation of L1 by CK-II - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2015-07-02
literatureReference	[LiteratureReference:445043] MAP kinase pathway-dependent phosphorylation of the L1-CAM ankyrin binding site regulates neuronal growth [LiteratureReference:445034] A MAP kinase-signaling pathway mediates neurite outgrowth on L1 and requires Src-dependent endocytosis [LiteratureReference:444930] Adhesion molecule L1 stimulates neuronal migration through Vav2-Pak1 signaling [LiteratureReference:391815] Neural recognition molecules of the immunoglobulin superfamily: signaling transducers of axon guidance and neuronal migration [LiteratureReference:444908] Activation of the MAPK signal cascade by the neural cell adhesion molecule L1 requires L1 internalization [LiteratureReference:444951] Close homolog of L1 is an enhancer of integrin-mediated cell migration
maxDepth	2
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	Signal transduction by L1
orthologousEvent	[Pathway:R-SCE-445144] Signal transduction by L1 - Saccharomyces cerevisiae [Pathway:R-DDI-445144] Signal transduction by L1 - Dictyostelium discoideum [Pathway:R-CEL-445144] Signal transduction by L1 - Caenorhabditis elegans [Pathway:R-DME-445144] Signal transduction by L1 - Drosophila melanogaster [Pathway:R-GGA-445144] Signal transduction by L1 - Gallus gallus [Pathway:R-DRE-445144] Signal transduction by L1 - Danio rerio [Pathway:R-SSC-445144] Signal transduction by L1 - Sus scrofa [Pathway:R-BTA-445144] Signal transduction by L1 - Bos taurus [Pathway:R-CFA-445144] Signal transduction by L1 - Canis familiaris [Pathway:R-RNO-445144] Signal transduction by L1 - Rattus norvegicus [Pathway:R-MMU-445144] Signal transduction by L1 - Mus musculus
releaseDate	2010-06-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:513001] Maness, PF, 2010-02-16
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-445144
summation	[Summation:445143] Besides adhesive roles in cell cell interaction, L1 function...
updateTrackers	[UpdateTracker:9786895] Update Tracker - [Pathway:445144] Signal transduction by L1 - v47:[removeHasEvent] [UpdateTracker:9784825] Update Tracker - [Pathway:445144] Signal transduction by L1 - v53:[updateContainedRLE] [UpdateTracker:9787855] Update Tracker - [Pathway:445144] Signal transduction by L1 - v44:[updateContainedRLE]

Referrals

(updatedInstance)	[UpdateTracker:9786895] Update Tracker - [Pathway:445144] Signal transduction by L1 - v47:[removeHasEvent] [UpdateTracker:9784825] Update Tracker - [Pathway:445144] Signal transduction by L1 - v53:[updateContainedRLE] [UpdateTracker:9787855] Update Tracker - [Pathway:445144] Signal transduction by L1 - v44:[updateContainedRLE]
(hasEvent)	[Pathway:R-HSA-373760] L1CAM interactions

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