Reactome | Signal transduction by L1

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Signal transduction by L1 Show undefined attributes

created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10222407
displayName	Signal transduction by L1
eventOf	[Pathway:R-RNO-373760] L1CAM interactions - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-RNO-374681] L1 and NCAM1 engaged in cis-interaction - Rattus norvegicus [Reaction:R-RNO-437230] L1-FGFR cis-heterodimerization - Rattus norvegicus [Reaction:R-RNO-445069] L1-EGFR trans-heterodimerization - Rattus norvegicus [Reaction:R-RNO-374669] L1 binds NRP1 - Rattus norvegicus [Reaction:R-RNO-374686] L1 interaction with Integrins - Rattus norvegicus [Reaction:R-RNO-445064] Activation of Rac1 by VAV2 - Rattus norvegicus [Reaction:R-RNO-445072] Interaction of PAK1 with Rac1-GTP - Rattus norvegicus [Reaction:R-RNO-109860] MAP2K1 phosphorylates MAPK3 - Rattus norvegicus [Reaction:R-RNO-109862] MAP2K2 phosphorylates MAPK1 - Rattus norvegicus [Reaction:R-RNO-392752] Phosphorylation of L1 by CK-II - Rattus norvegicus
inferredFrom	[Pathway:R-HSA-445144] Signal transduction by L1 - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Signal transduction by L1
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48895] Rattus norvegicus
stId	R-RNO-445144
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-373760] L1CAM interactions
(inferredTo)	[Pathway:R-HSA-445144] Signal transduction by L1

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