Reactome | MAP2K2 phosphorylates MAPK1

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MAP2K2 phosphorylates MAPK1 Show undefined attributes

authored	[InstanceEdit:158672] Charalambous, M, 2005-02-04 06:50:22
catalystActivity	[CatalystActivity:109861] protein serine/threonine kinase activity of p-S,T-MAP2K2:MAPK1 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:112400] Charalambous, M, 2004-04-29 09:21:24
dbId	109862
displayName	MAP2K2 phosphorylates MAPK1
edited	[InstanceEdit:165100] Schmidt, EE, 0000-00-00 00:00:00
eventOf	[Pathway:R-HSA-112411] MAPK1 (ERK2) activation - Homo sapiens [Pathway:R-HSA-445144] Signal transduction by L1 - Homo sapiens
figure	[Figure:158670] /figures/MEK_P_ERK.jpg
followingEvent	[Reaction:R-HSA-109864] Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2 - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-109849] p-S,T-MAP2K2:MAPK1 [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:110054] Cloning and characterization of two distinct human extracellular signal-regulated kinase activator kinases, MEK1 and MEK2. [LiteratureReference:5673960] MEK1/2 dual-specificity protein kinases: structure and regulation
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	MAP2K2 phosphorylates MAPK1
orthologousEvent	[Reaction:R-GGA-451516] activated MEK2 phosphorylates ERK2 - Gallus gallus [Reaction:R-DDI-109862] MAP2K2 phosphorylates MAPK1 - Dictyostelium discoideum [Reaction:R-CEL-109862] MAP2K2 phosphorylates MAPK1 - Caenorhabditis elegans [Reaction:R-DME-109862] MAP2K2 phosphorylates MAPK1 - Drosophila melanogaster [Reaction:R-DRE-109862] MAP2K2 phosphorylates MAPK1 - Danio rerio [Reaction:R-SSC-109862] MAP2K2 phosphorylates MAPK1 - Sus scrofa [Reaction:R-CFA-109862] MAP2K2 phosphorylates MAPK1 - Canis familiaris [Reaction:R-RNO-109862] MAP2K2 phosphorylates MAPK1 - Rattus norvegicus [Reaction:R-MMU-109862] MAP2K2 phosphorylates MAPK1 - Mus musculus
output	2 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-109854] p-S,T-MAP2K2:p-T,Y-MAPK1 [cytosol]
precedingEvent	[Reaction:R-HSA-109858] MAP2K2 binds MAPK1 - Homo sapiens
releaseDate	2010-12-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:202668] Greene, LA, 2007-11-08 15:39:37
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-109862
summation	[Summation:158666] MAP2K2 (MEK2) phosphorylates MAPK1 (ERK2). Phosphorylation o...
updateTrackers	[UpdateTracker:9784631] Update Tracker - [Reaction:109862] MAP2K2 phosphorylates MAPK1 - v53:[addLiteratureReference, modifyText]

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(updatedInstance)	[UpdateTracker:9784631] Update Tracker - [Reaction:109862] MAP2K2 phosphorylates MAPK1 - v53:[addLiteratureReference, modifyText]
(hasEvent)	[Pathway:R-HSA-445144] Signal transduction by L1 [Pathway:R-HSA-112411] MAPK1 (ERK2) activation
(precedingEvent)	[Reaction:R-HSA-109864] Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2