Reactome | MAP2K1 phosphorylates MAPK3

Schema > Reaction > Entries

MAP2K1 phosphorylates MAPK3 Show undefined attributes

authored	[InstanceEdit:158672] Charalambous, M, 2005-02-04 06:50:22
catalystActivity	[CatalystActivity:109859] protein serine/threonine kinase activity of p-2S-MAP2K1:MAPK3 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:112400] Charalambous, M, 2004-04-29 09:21:24
dbId	109860
displayName	MAP2K1 phosphorylates MAPK3
edited	[InstanceEdit:165100] Schmidt, EE, 0000-00-00 00:00:00
eventOf	[Pathway:R-HSA-110056] MAPK3 (ERK1) activation - Homo sapiens [Pathway:R-HSA-445144] Signal transduction by L1 - Homo sapiens
figure	[Figure:158670] /figures/MEK_P_ERK.jpg
followingEvent	[BlackBoxEvent:R-HSA-109863] Dissociation of p-T,Y-MAPK3:MAP2K1 - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-109838] p-2S-MAP2K1:MAPK3 [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:110054] Cloning and characterization of two distinct human extracellular signal-regulated kinase activator kinases, MEK1 and MEK2. [LiteratureReference:5684202] Mitogen-activated protein kinases in innate immunity [LiteratureReference:5673960] MEK1/2 dual-specificity protein kinases: structure and regulation
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	MAP2K1 phosphorylates MAPK3
orthologousEvent	[Reaction:R-DDI-109860] MAP2K1 phosphorylates MAPK3 - Dictyostelium discoideum [Reaction:R-CEL-109860] MAP2K1 phosphorylates MAPK3 - Caenorhabditis elegans [Reaction:R-DME-109860] MAP2K1 phosphorylates MAPK3 - Drosophila melanogaster [Reaction:R-DRE-109860] MAP2K1 phosphorylates MAPK3 - Danio rerio [Reaction:R-BTA-109860] MAP2K1 phosphorylates MAPK3 - Bos taurus [Reaction:R-RNO-109860] MAP2K1 phosphorylates MAPK3 - Rattus norvegicus [Reaction:R-MMU-109860] MAP2K1 phosphorylates MAPK3 - Mus musculus
output	2 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-109843] p-T,Y-MAPK3:p-2S-MAP2K1 [cytosol]
precedingEvent	[Reaction:R-HSA-109857] MAP2K1 binds MAPK3 - Homo sapiens
regulatedBy	[NegativeRegulation:R-HSA-112343] Negative regulation by 'p-2T-MAP2K1 [cytosol]'
releaseDate	2005-06-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:202668] Greene, LA, 2007-11-08 15:39:37
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-109860
summation	[Summation:158667] MAP2K1 (also known as MEK1) phosphorylates the critical Thr2...
updateTrackers	[UpdateTracker:9784797] Update Tracker - [Reaction:109860] MAP2K1 phosphorylates MAPK3 - v53:[addLiteratureReference, modifyText] [UpdateTracker:9790806] Update Tracker - [Reaction:109860] MAP2K1 phosphorylates MAPK3 - v33:[add_removeRegulator]

Referrals

(updatedInstance)	[UpdateTracker:9784797] Update Tracker - [Reaction:109860] MAP2K1 phosphorylates MAPK3 - v53:[addLiteratureReference, modifyText] [UpdateTracker:9790806] Update Tracker - [Reaction:109860] MAP2K1 phosphorylates MAPK3 - v33:[add_removeRegulator]
(hasEvent)	[Pathway:R-HSA-445144] Signal transduction by L1 [Pathway:R-HSA-110056] MAPK3 (ERK1) activation
(precedingEvent)	[BlackBoxEvent:R-HSA-109863] Dissociation of p-T,Y-MAPK3:MAP2K1