Reactome | Phosphorylation of CREB1 by ribosomal protein S6 kinases (RSKs)

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Phosphorylation of CREB1 by ribosomal protein S6 kinases (RSKs) Show undefined attributes

authored	[InstanceEdit:445353] Mahajan, SS, 2009-10-29
catalystActivity	[CatalystActivity:442985] protein serine/threonine kinase activity of p-S221,T359,S363,S380,T573,T732-RSK [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:442716] Mahajan, SS, 2009-09-29
dbId	442724
displayName	Phosphorylation of CREB1 by ribosomal protein S6 kinases (RSKs)
edited	[InstanceEdit:422554] Gillespie, ME, 2009-06-02 00:56:21 [InstanceEdit:9628239] Orlic-Milacic, Marija, 2018-11-07
eventOf	[Pathway:R-HSA-442742] CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling - Homo sapiens
followingEvent	[Reaction:R-HSA-9031610] p-S133 CREB1, MEF2D and SRF bind the ARC gene - Homo sapiens [Reaction:R-HSA-111916] Dimerization of p-S133-CREB1 - Homo sapiens
input	[SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-52777] CREB1 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:442988] Cognitive impairment in Coffin-Lowry syndrome correlates with reduced RSK2 activation [LiteratureReference:9620135] Induction of MUC8 gene expression by interleukin-1 beta is mediated by a sequential ERK MAPK/RSK1/CREB cascade pathway in human airway epithelial cells [LiteratureReference:199893] Rsk-2 activity is necessary for epidermal growth factor-induced phosphorylation of CREB protein and transcription of c-fos gene [LiteratureReference:9620151] Stimulation of endothelin B receptors in astrocytes induces cAMP response element-binding protein phosphorylation and c-fos expression via multiple mitogen-activated protein kinase signaling pathways
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	Phosphorylation of CREB1 by ribosomal protein S6 kinases (RSKs)
orthologousEvent	[Reaction:R-CEL-442724] Phosphorylation of CREB1 by ribosomal protein S6 kinases (RSKs) - Caenorhabditis elegans [Reaction:R-DME-442724] Phosphorylation of CREB1 by ribosomal protein S6 kinases (RSKs) - Drosophila melanogaster [Reaction:R-GGA-442724] Phosphorylation of CREB1 by ribosomal protein S6 kinases (RSKs) - Gallus gallus [Reaction:R-XTR-442724] Phosphorylation of CREB1 by ribosomal protein S6 kinases (RSKs) - Xenopus tropicalis [Reaction:R-DRE-442724] Phosphorylation of CREB1 by ribosomal protein S6 kinases (RSKs) - Danio rerio [Reaction:R-SSC-442724] Phosphorylation of CREB1 by ribosomal protein S6 kinases (RSKs) - Sus scrofa [Reaction:R-BTA-442724] Phosphorylation of CREB1 by ribosomal protein S6 kinases (RSKs) - Bos taurus [Reaction:R-CFA-442724] Phosphorylation of CREB1 by ribosomal protein S6 kinases (RSKs) - Canis familiaris [Reaction:R-RNO-442724] Phosphorylation of CREB1 by ribosomal protein S6 kinases (RSKs) - Rattus norvegicus [Reaction:R-MMU-442724] Phosphorylation of CREB1 by ribosomal protein S6 kinases (RSKs) - Mus musculus
output	[SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-111910] p-S133-CREB1 [nucleoplasm]
precedingEvent	[Reaction:R-HSA-442739] PDPK1 phosphorylates RSKs - Homo sapiens
releaseDate	2009-12-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:446792] Tukey, D, 2009-11-17 [InstanceEdit:9627687] Yi, Feng, 2018-11-02 [InstanceEdit:9628437] Hansen, Kasper B, 2018-11-02
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-442724
summation	[Summation:444308] CREB1 is phosphorylated at serine residue S133 by any of the...
updateTrackers	[UpdateTracker:9790168] Update Tracker - [Reaction:442724] Phosphorylation of CREB1 by ribosomal protein S6 kinases (RSKs) - v35:[removeOutput] [UpdateTracker:9778755] Update Tracker - [Reaction:442724] Phosphorylation of CREB1 by ribosomal protein S6 kinases (RSKs) - v67:[addLiteratureReference, modifyText] [UpdateTracker:9846652] Update Tracker - [Reaction:442724] Phosphorylation of CREB1 by ribosomal protein S6 kinases (RSKs) - v84:[modifyText] [UpdateTracker:9864322] Update Tracker - [Reaction:442724] Phosphorylation of CREB1 by ribosomal protein S6 kinases (RSKs) - v88:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9790168] Update Tracker - [Reaction:442724] Phosphorylation of CREB1 by ribosomal protein S6 kinases (RSKs) - v35:[removeOutput] [UpdateTracker:9778755] Update Tracker - [Reaction:442724] Phosphorylation of CREB1 by ribosomal protein S6 kinases (RSKs) - v67:[addLiteratureReference, modifyText] [UpdateTracker:9846652] Update Tracker - [Reaction:442724] Phosphorylation of CREB1 by ribosomal protein S6 kinases (RSKs) - v84:[modifyText] [UpdateTracker:9864322] Update Tracker - [Reaction:442724] Phosphorylation of CREB1 by ribosomal protein S6 kinases (RSKs) - v88:[modifyText]
(hasEvent)	[Pathway:R-HSA-442742] CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
(precedingEvent)	[Reaction:R-HSA-9031610] p-S133 CREB1, MEF2D and SRF bind the ARC gene [Reaction:R-HSA-111916] Dimerization of p-S133-CREB1

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