Reactome | Unblocking of NMDA receptors, glutamate binding and activation

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Unblocking of NMDA receptors, glutamate binding and activation Show undefined attributes

authored	[InstanceEdit:445353] Mahajan, SS, 2009-10-29
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:438065] Mahajan, SS, 2009-09-23
dbId	438066
displayName	Unblocking of NMDA receptors, glutamate binding and activation
edited	[InstanceEdit:447013] Gillespie, ME, 2009-11-19 [InstanceEdit:9615242] Orlic-Milacic, Marija, 2018-07-31 [InstanceEdit:9628239] Orlic-Milacic, Marija, 2018-11-07
eventOf	[Pathway:R-HSA-442755] Activation of NMDA receptors and postsynaptic events - Homo sapiens
followingEvent	[Pathway:R-HSA-438064] Post NMDA receptor activation events - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:1221473] regulation of NMDA receptor activity
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-9614185] Mg2+ binds GRIN1:GRIN2 NMDA receptors - Homo sapiens [Reaction:R-HSA-432172] Glycine and glutamate ligands bind GRIN1:GRIN2 NMDA receptor - Homo sapiens [Reaction:R-HSA-438037] Membrane depolarization upon activation of Ca impermeable AMPA receptors - Homo sapiens [Reaction:R-HSA-432162] Unblocking of GRIN1:GRIN2 NMDA receptors - Homo sapiens [Reaction:R-HSA-432164] Ca2+ influx into the post-synaptic cell - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2019-03-25
literatureReference	[LiteratureReference:9609810] NMDA receptor subunit diversity: impact on receptor properties, synaptic plasticity and disease [LiteratureReference:9609821] NMDA receptors: linking physiological output to biophysical operation [LiteratureReference:9627458] Glutamate receptor ion channels: structure, regulation, and function
maxDepth	2
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	Unblocking of NMDA receptors, glutamate binding and activation
orthologousEvent	[Pathway:R-CEL-438066] Unblocking of NMDA receptors, glutamate binding and activation - Caenorhabditis elegans [Pathway:R-DME-438066] Unblocking of NMDA receptors, glutamate binding and activation - Drosophila melanogaster [Pathway:R-GGA-438066] Unblocking of NMDA receptors, glutamate binding and activation - Gallus gallus [Pathway:R-XTR-438066] Unblocking of NMDA receptors, glutamate binding and activation - Xenopus tropicalis [Pathway:R-DRE-438066] Unblocking of NMDA receptors, glutamate binding and activation - Danio rerio [Pathway:R-SSC-438066] Unblocking of NMDA receptors, glutamate binding and activation - Sus scrofa [Pathway:R-BTA-438066] Unblocking of NMDA receptors, glutamate binding and activation - Bos taurus [Pathway:R-CFA-438066] Unblocking of NMDA receptors, glutamate binding and activation - Canis familiaris [Pathway:R-RNO-438066] Unblocking of NMDA receptors, glutamate binding and activation - Rattus norvegicus [Pathway:R-MMU-438066] Unblocking of NMDA receptors, glutamate binding and activation - Mus musculus
releaseDate	2009-12-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:446792] Tukey, D, 2009-11-17 [InstanceEdit:9627687] Yi, Feng, 2018-11-02 [InstanceEdit:9628437] Hansen, Kasper B, 2018-11-02
revised	[InstanceEdit:9624342] Orlic-Milacic, Marija, 2018-10-10
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-438066
summation	[Summation:444365] At resting membrane potential, the NMDA receptor ion channel...
updateTrackers	[UpdateTracker:9779244] Update Tracker - [Pathway:438066] Unblocking of NMDA receptors, glutamate binding and activation - v66:[addHasEvent, add_removeLiteratureReference, modifyText, updateContainedRLE] [UpdateTracker:9783715] Update Tracker - [Pathway:438066] Unblocking of NMDA receptors, glutamate binding and activation - v56:[updateContainedRLE] [UpdateTracker:9778753] Update Tracker - [Pathway:438066] Unblocking of NMDA receptors, glutamate binding and activation - v67:[addLiteratureReference, modifyText, updateContainedRLE] [UpdateTracker:9786328] Update Tracker - [Pathway:438066] Unblocking of NMDA receptors, glutamate binding and activation - v50:[updateContainedRLE] [UpdateTracker:9777970] Update Tracker - [Pathway:438066] Unblocking of NMDA receptors, glutamate binding and activation - v68:[updateContainedRLE]

Referrals

(updatedInstance)	[UpdateTracker:9779244] Update Tracker - [Pathway:438066] Unblocking of NMDA receptors, glutamate binding and activation - v66:[addHasEvent, add_removeLiteratureReference, modifyText, updateContainedRLE] [UpdateTracker:9783715] Update Tracker - [Pathway:438066] Unblocking of NMDA receptors, glutamate binding and activation - v56:[updateContainedRLE] [UpdateTracker:9778753] Update Tracker - [Pathway:438066] Unblocking of NMDA receptors, glutamate binding and activation - v67:[addLiteratureReference, modifyText, updateContainedRLE] [UpdateTracker:9786328] Update Tracker - [Pathway:438066] Unblocking of NMDA receptors, glutamate binding and activation - v50:[updateContainedRLE] [UpdateTracker:9777970] Update Tracker - [Pathway:438066] Unblocking of NMDA receptors, glutamate binding and activation - v68:[updateContainedRLE]
(hasEvent)	[Pathway:R-HSA-442755] Activation of NMDA receptors and postsynaptic events
(precedingEvent)	[Pathway:R-HSA-438064] Post NMDA receptor activation events

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