At resting membrane potential, the NMDA receptor ion channel...

created [InstanceEdit:444364] Mahajan, SS, 2009-10-23
dbId 444365
displayName At resting membrane potential, the NMDA receptor ion channel...
modified [InstanceEdit:9627467] Orlic-Milacic, Marija, 2018-11-02
schemaClass Summation
text At resting membrane potential, the NMDA receptor ion channel is blocked by extracellular Mg2+ ions and is unable to mediate ion permeation upon binding of ligands (glutamate, glycine, D-serine, NMDA). The voltage block is removed upon depolarization of the post-synaptic cell membrane and Mg2+ is expelled from the NMDA receptor pore (channel), resulting in activated ligand-bound NMDA receptors. The depolarization of the membrane may happen in response to activation of Ca2+ impermeable AMPA receptors, which facilitates Na+ influx, contributing to the unblocking of NMDA receptors. For review, please refer to Traynelis et al. 2010, Paoletti et al. 2013, and Iacobucci and Popescu 2017.
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