Reactome | Ca2+ influx into the post-synaptic cell

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Ca2+ influx into the post-synaptic cell Show undefined attributes

authored	[InstanceEdit:445353] Mahajan, SS, 2009-10-29
catalystActivity	[CatalystActivity:432784] excitatory extracellular ligand-gated monoatomic ion channel activity of Gly,D-Ser:L-Glu:GRIN1:GRIN2 NMDA receptors [plasma membrane]
category	transition
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:432163] Mahajan, SS, 2009-08-12
crossReference	[DatabaseIdentifier:12667421] RHEA:29671
dbId	432164
displayName	Ca2+ influx into the post-synaptic cell
edited	[InstanceEdit:422554] Gillespie, ME, 2009-06-02 00:56:21 [InstanceEdit:9628239] Orlic-Milacic, Marija, 2018-11-07
eventOf	[Pathway:R-HSA-438066] Unblocking of NMDA receptors, glutamate binding and activation - Homo sapiens
followingEvent	[Reaction:R-HSA-9618811] Calcium binds calmodulin at the synapse - Homo sapiens
input	[SimpleEntity:R-ALL-74112] Ca2+ [extracellular region]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:442700] Activation of peripheral NMDA receptors contributes to human pain and rat afferent discharges evoked by injection of glutamate into the masseter muscle
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	Ca2+ influx into the post-synaptic cell
orthologousEvent	[Reaction:R-CEL-432164] Ca2+ influx into the post-synaptic cell - Caenorhabditis elegans [Reaction:R-DME-432164] Ca2+ influx into the post-synaptic cell - Drosophila melanogaster [Reaction:R-GGA-432164] Ca2+ influx into the post-synaptic cell - Gallus gallus [Reaction:R-XTR-432164] Ca2+ influx into the post-synaptic cell - Xenopus tropicalis [Reaction:R-DRE-432164] Ca2+ influx into the post-synaptic cell - Danio rerio [Reaction:R-SSC-432164] Ca2+ influx into the post-synaptic cell - Sus scrofa [Reaction:R-BTA-432164] Ca2+ influx into the post-synaptic cell - Bos taurus [Reaction:R-CFA-432164] Ca2+ influx into the post-synaptic cell - Canis familiaris [Reaction:R-RNO-432164] Ca2+ influx into the post-synaptic cell - Rattus norvegicus [Reaction:R-MMU-432164] Ca2+ influx into the post-synaptic cell - Mus musculus
output	[SimpleEntity:R-ALL-74016] Ca2+ [cytosol]
precedingEvent	[Reaction:R-HSA-432172] Glycine and glutamate ligands bind GRIN1:GRIN2 NMDA receptor - Homo sapiens
regulatedBy	[NegativeRegulation:9635205] Negative regulation by 'Ifenprodil [extracellular region]'
releaseDate	2009-12-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:446792] Tukey, D, 2009-11-17 [InstanceEdit:9627687] Yi, Feng, 2018-11-02 [InstanceEdit:9628437] Hansen, Kasper B, 2018-11-02
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-432164
summation	[Summation:444217] NMDA receptors are activated upon binding of two ligands, gl...
updateTrackers	[UpdateTracker:9778767] Update Tracker - [Reaction:432164] Ca2+ influx into the post-synaptic cell - v67:[modifyText] [UpdateTracker:9783467] Update Tracker - [Reaction:432164] Ca2+ influx into the post-synaptic cell - v56:[removeInput, removeOutput] [UpdateTracker:9778292] Update Tracker - [Reaction:432164] Ca2+ influx into the post-synaptic cell - v68:[addRegulator]

Referrals

(updatedInstance)	[UpdateTracker:9778767] Update Tracker - [Reaction:432164] Ca2+ influx into the post-synaptic cell - v67:[modifyText] [UpdateTracker:9783467] Update Tracker - [Reaction:432164] Ca2+ influx into the post-synaptic cell - v56:[removeInput, removeOutput] [UpdateTracker:9778292] Update Tracker - [Reaction:432164] Ca2+ influx into the post-synaptic cell - v68:[addRegulator]
(hasEvent)	[Pathway:R-HSA-438066] Unblocking of NMDA receptors, glutamate binding and activation
(precedingEvent)	[Reaction:R-HSA-9618811] Calcium binds calmodulin at the synapse

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