Unblocking of NMDA receptors, glutamate binding and activation

Stable Identifier
R-HSA-438066
Type
Pathway
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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Unblocking of NMDA receptors, glutamate binding and activation
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At resting membrane potential, the NMDA receptor ion channel is blocked by extracellular Mg2+ ions and is unable to mediate ion permeation upon binding of ligands (glutamate, glycine, D-serine, NMDA). The voltage block is removed upon depolarization of the post-synaptic cell membrane and Mg2+ is expelled from the NMDA receptor pore (channel), resulting in activated ligand-bound NMDA receptors. The depolarization of the membrane may happen in response to activation of Ca2+ impermeable AMPA receptors, which facilitates Na+ influx, contributing to the unblocking of NMDA receptors. For review, please refer to Traynelis et al. 2010, Paoletti et al. 2013, and Iacobucci and Popescu 2017.

Literature References
PubMed ID Title Journal Year
28303017 NMDA receptors: linking physiological output to biophysical operation

Popescu, GK, Iacobucci, GJ

Nat. Rev. Neurosci. 2017
20716669 Glutamate receptor ion channels: structure, regulation, and function

Myers, SJ, Dingledine, R, Ogden, KK, Wollmuth, LP, Menniti, FS, Hansen, KB, Vance, KM, Yuan, H, Traynelis, SF, McBain, CJ

Pharmacol. Rev. 2010
23686171 NMDA receptor subunit diversity: impact on receptor properties, synaptic plasticity and disease

Zhou, Q, Paoletti, P, Bellone, C

Nat. Rev. Neurosci. 2013
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Event Information
Go Biological Process
regulation of NMDA receptor activity (2000310)
Orthologous Events
Unblocking of NMDA receptors, glutamate binding and activation (Bos taurus)
Unblocking of NMDA receptors, glutamate binding and activation (Caenorhabditis elegans)
Unblocking of NMDA receptors, glutamate binding and activation (Canis familiaris)
Unblocking of NMDA receptors, glutamate binding and activation (Danio rerio)
Unblocking of NMDA receptors, glutamate binding and activation (Drosophila melanogaster)
Unblocking of NMDA receptors, glutamate binding and activation (Gallus gallus)
Unblocking of NMDA receptors, glutamate binding and activation (Mus musculus)
Unblocking of NMDA receptors, glutamate binding and activation (Rattus norvegicus)
Unblocking of NMDA receptors, glutamate binding and activation (Sus scrofa)
Unblocking of NMDA receptors, glutamate binding and activation (Xenopus tropicalis)
Authored
Mahajan, SS  (2009-10-29)
Reviewed
Tukey, D  (2009-11-18)
Hansen, KB  (2018-11-02)
Yi, F  (2018-11-02)
Created
Mahajan, SS  (2009-09-23)
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