Translocation and activation of PKC alpha in response to WNT signaling

Stable Identifier
R-HSA-4332390
Type
Reaction
Species
Homo sapiens
Compartment
cytosol, plasma membrane
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Translocation and activation of PKC alpha in response to WNT signaling
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Ectopic expression of Xwnt5a or Rfz2 in Xenopus embryos results in PKC translocation to the plasma membrane in a G-protein-dependent manner (Sheldahl et al, 1999; reviewed in Kuhl et al, 2000). PKC activation in response to WNT5A has also been demonstrated in human metastatic melanoma cell lines, contributing to cytoskeletal reorganization leading to invasiveness and motility as well as promoting the epithelial to mesenchymal transition (Weeraratna et al, 2002; Dissanyake et al, 2007; O'Connell et al, 2009)

Literature References
PubMed ID Title Journal Year
10858654 The Wnt/Ca2+ pathway: a new vertebrate Wnt signaling pathway takes shape

Sheldahl, LC, Kühl, M, Moon, RT, Miller, JR, Park, M

Trends Genet. 2000
17426020 The Wnt5A/protein kinase C pathway mediates motility in melanoma cells via the inhibition of metastasis suppressors and initiation of an epithelial to mesenchymal transition

Taub, DD, Hewitt, KJ, Shah, KV, Jiang, Y, Rosenthal, DT, Indig, FE, Bittner, M, Dissanayake, SK, Moon, RT, Johnson, CE, O'Connell, MP, Weeraratna, AT, Nickoloff, BJ, French, AD, Trent, JM, Leotlela, PD, Wade, M

J. Biol. Chem. 2007
12086864 Wnt5a signaling directly affects cell motility and invasion of metastatic melanoma

Duray, P, Weeraratna, AT, Hostetter, G, Jiang, Y, Rosenblatt, K, Trent, JM, Bittner, M

Cancer Cell 2002
19177143 Wnt5A activates the calpain-mediated cleavage of filamin A

Taub, DD, Baugher, KM, Hasskamp, JH, Frank, BP, Indig, FE, Hoek, KS, Earley, R, Fiori, JL, O'Connell, MP, Weeraratna, AT, Elias, EG, French, AD, Camilli, TC, Bernier, M

J. Invest. Dermatol. 2009
10395542 Protein kinase C is differentially stimulated by Wnt and Frizzled homologs in a G-protein-dependent manner

Moon, RT, Sheldahl, LC, Park, M, Malbon, CC

Curr. Biol. 1999
Participants
Input
Output
Participates
as an event of
Inferred From
translocation of Xenopus prkca to plasma membrane (Xenopus laevis)
Authored
Rothfels, K  (2013-08-29)
Reviewed
Kikuchi, A  (2013-11-12)
Created
Rothfels, K  (2013-08-16)
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