Ectopic expression of Xwnt5a or Rfz2 in Xenopus embryos resu...

created [InstanceEdit:4518586] Rothfels, K, 2013-09-03
dbId 4518587
displayName Ectopic expression of Xwnt5a or Rfz2 in Xenopus embryos resu...
modified [InstanceEdit:4663872] Rothfels, K, 2013-10-07
schemaClass Summation
text Ectopic expression of Xwnt5a or Rfz2 in Xenopus embryos results in PKC translocation to the plasma membrane in a G-protein-dependent manner (Sheldahl et al, 1999; reviewed in Kuhl et al, 2000). PKC activation in response to WNT5A has also been demonstrated in human metastatic melanoma cell lines, contributing to cytoskeletal reorganization leading to invasiveness and motility as well as promoting the epithelial to mesenchymal transition (Weeraratna et al, 2002; Dissanyake et al, 2007; O'Connell et al, 2009)
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