Reactome | SGMS2 transfers phosphocholine onto ceramide

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SGMS2 transfers phosphocholine onto ceramide Show undefined attributes

catalystActivity	[CatalystActivity:10016202] sphingomyelin synthase activity of 2xPalmC-SGMS2 [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10016204
displayName	SGMS2 transfers phosphocholine onto ceramide
eventOf	[Pathway:R-MMU-1660661] Sphingolipid de novo biosynthesis - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-1606273] SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane) - Mus musculus [Reaction:R-MMU-1640164] ENPP7 hydrolyzes sphingomyelin - Mus musculus
inferredFrom	[Reaction:R-HSA-429786] SGMS2 transfers phosphocholine onto ceramide - Homo sapiens
input	[SimpleEntity:R-ALL-429807] CERA [plasma membrane] [SimpleEntity:R-ALL-429802] PC [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	SGMS2 transfers phosphocholine onto ceramide phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS2]
output	[SimpleEntity:R-ALL-114519] DAG [plasma membrane] [SimpleEntity:R-ALL-9843210] SPHM [plasma membrane]
precedingEvent	[Reaction:R-MMU-1606273] SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane) - Mus musculus [Reaction:R-MMU-1640164] ENPP7 hydrolyzes sphingomyelin - Mus musculus [Reaction:R-MMU-1861788] GBA2 hydrolyzes GlcCer (plasma membrane) - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-429786
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-1660661] Sphingolipid de novo biosynthesis
(precedingEvent)	[Reaction:R-MMU-1606273] SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane) [Reaction:R-MMU-1640164] ENPP7 hydrolyzes sphingomyelin
(inferredTo)	[Reaction:R-HSA-429786] SGMS2 transfers phosphocholine onto ceramide

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