Reactome | SLC5A8 (SMCT) co-transports monocarboxylates and Na+ from extracellular region to cytosol

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SLC5A8 (SMCT) co-transports monocarboxylates and Na+ from extracellular region to cytosol Show undefined attributes

catalystActivity	[CatalystActivity:10585438] monocarboxylic acid transmembrane transporter activity of SLC5A8 [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10585440
displayName	SLC5A8 (SMCT) co-transports monocarboxylates and Na+ from extracellular region to cytosol
eventOf	[Pathway:R-DRE-428643] Organic anion transport by SLC5/17/25 transporters - Danio rerio [Pathway:R-DRE-196807] Nicotinate metabolism - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DRE-197186] NAPRT1 dimer transfers PRIB to NCA to form NAMN - Danio rerio [Reaction:R-DRE-561253] SLC22A12 exchanges extracellular urate for cytosolic LACT - Danio rerio
inferredFrom	[Reaction:R-HSA-429749] SLC5A8 (SMCT) co-transports monocarboxylates and Na+ from extracellular region to cytosol - Homo sapiens
input	[DefinedSet:R-ALL-429739] monocarboxylates transported by SLC5A8 [extracellular region] 2 × [SimpleEntity:R-ALL-74113] Na+ [extracellular region]
isInDisease	false
isInferred	true
maxDepth	1
name	SLC5A8 (SMCT) co-transports monocarboxylates and Na+ from extracellular region to cytosol (S)-lactate(out) + 2 Na(+)(out) = (S)-lactate(in) + 2 Na(+)(in) acetate(out) + 2 Na(+)(out) = acetate(in) + 2 Na(+)(in) butanoate(out) + 2 Na(+)(out) = butanoate(in) + 2 Na(+)(in) propanoate(out) + 2 Na(+)(out) = propanoate(in) + 2 Na(+)(in) pyruvate(out) + 2 Na(+)(out) = pyruvate(in) + 2 Na(+)(in)
output	[DefinedSet:R-ALL-429748] monocarboxylates transported by SLC5A8 [cytosol] 2 × [SimpleEntity:R-ALL-83910] Na+ [cytosol]
precedingEvent	[Reaction:R-DRE-373875] BSG:MCTs cotransport LACT, H+ from cytosol to extracellular region - Danio rerio [Reaction:R-DRE-561253] SLC22A12 exchanges extracellular urate for cytosolic LACT - Danio rerio
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-429749
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-428643] Organic anion transport by SLC5/17/25 transporters [Pathway:R-DRE-196807] Nicotinate metabolism
(precedingEvent)	[Reaction:R-DRE-197186] NAPRT1 dimer transfers PRIB to NCA to form NAMN [Reaction:R-DRE-561253] SLC22A12 exchanges extracellular urate for cytosolic LACT
(inferredTo)	[Reaction:R-HSA-429749] SLC5A8 (SMCT) co-transports monocarboxylates and Na+ from extracellular region to cytosol

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