Reactome | SLP-76 stimulates PLC gamma 2

SLP-76 stimulates PLC gamma 2

Stable Identifier

R-HSA-429497

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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SLP-76 has a well-established role in recruitment of PLC gamma 1 in immunoreceptor signalling; its role in the recruitment of PLC gamma 2 in integrin signalling is less clear. Results from SLP-76 null mice imply a functional role in GPVI signalling. Platelets from SLP-76 null mice exhibit a marked reduction in spreading and a decrease in whole cell phosphotyrosine levels when adhered to a fibrinogen-coated surface. In vivo reconstitution of SLP-76 by retroviral gene transfer corrects bleeding diathesis and restores normal responses to both collagen and fibrinogen (Judd et al., 2000).

Literature References

PubMed ID	Title	Journal	Year
10469124	Evidence that phospholipase C-gamma2 interacts with SLP-76, Syk, Lyn, LAT and the Fc receptor gamma-chain after stimulation of the collagen receptor glycoprotein VI in human platelets Gross, BS, Melford, SK, Watson, SP	Eur J Biochem	1999
12813055	Signaling role for phospholipase C gamma 2 in platelet glycoprotein Ib alpha calcium flux and cytoskeletal reorganization. Involvement of a pathway distinct from FcR gamma chain and Fc gamma RIIA Mangin, P, Yuan, Y, Goncalves, I, Eckly, A, Freund, M, Cazenave, JP, Gachet, C, Jackson, SP, Lanza, F	J Biol Chem	2003
12832405	Integrin alpha IIb beta 3-dependent calcium signals regulate platelet-fibrinogen interactions under flow. Involvement of phospholipase C gamma 2 Goncalves, I, Hughan, SC, Schoenwaelder, SM, Yap, CL, Yuan, Y, Jackson, SP	J Biol Chem	2003