Reactome | SLP-76 stimulates PLC gamma 2

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SLP-76 stimulates PLC gamma 2 Show undefined attributes

category	omitted
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10138828
displayName	SLP-76 stimulates PLC gamma 2
eventOf	[Pathway:R-RNO-114604] GPVI-mediated activation cascade - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-114689] PLC gamma 2-mediated PIP2 hydrolysis - Rattus norvegicus
inferredFrom	[BlackBoxEvent:R-HSA-429497] SLP-76 stimulates PLC gamma 2 - Homo sapiens
input	[EntityWithAccessionedSequence:R-RNO-2685588] Plcg2 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	SLP-76 stimulates PLC gamma 2
output	[EntityWithAccessionedSequence:R-RNO-114602] phospho-Plcg2 [plasma membrane]
precedingEvent	[Reaction:R-RNO-429449] Syk activation leads to SLP-76 activation - Rattus norvegicus
regulatedBy	[PositiveRegulation:10138829] Positive regulation by 'p-Y113,128,145-LCP2 [cytosol]'
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:48895] Rattus norvegicus
stId	R-RNO-429497
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-114604] GPVI-mediated activation cascade
(precedingEvent)	[Reaction:R-RNO-114689] PLC gamma 2-mediated PIP2 hydrolysis
(inferredTo)	[BlackBoxEvent:R-HSA-429497] SLP-76 stimulates PLC gamma 2

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