Reactome | SLC27A1 transports arachidonate across the ER membrane

authored	[InstanceEdit:428984] Jupe, S, 2009-07-14
catalystActivity	[CatalystActivity:9915567] icosanoid transmembrane transporter activity of SLC27A1 [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:17957] endoplasmic reticulum lumen [Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:428989] Jupe, S, 2009-07-14
crossReference	[DatabaseIdentifier:12667467] RHEA:71395 [DatabaseIdentifier:9915558] RHEA:71395
dbId	428990
displayName	SLC27A1 transports arachidonate across the ER membrane
edited	[InstanceEdit:428989] Jupe, S, 2009-07-14
eventOf	[Pathway:R-HSA-2142753] Arachidonate metabolism - Homo sapiens
followingEvent	[Reaction:R-HSA-2161948] Arachidonate is converted to 12-oxoETE by ALOX12 - Homo sapiens [Reaction:R-HSA-2161964] Arachidonate is oxidised to 12S-HpETE by ALOX12/15 - Homo sapiens [Reaction:R-HSA-2161950] Arachidonate is oxidised to 12R-HpETE by ALOX12B - Homo sapiens [Reaction:R-HSA-2161951] Arachidonate is oxidised to 15R-HETE by Acetyl-PTGS2 - Homo sapiens [Reaction:R-HSA-9915997] Arachidonate is epoxidated to 14,15-EET by CYP(5) - Homo sapiens [Reaction:R-HSA-2161899] Arachidonate is epoxidated to 8,9-EET by CYP(5) - Homo sapiens [Reaction:R-HSA-9915971] Arachidonate is epoxidated to 11,12-EET by CYP(5) - Homo sapiens [Reaction:R-HSA-2161890] Arachidonate is epoxidated to 5,6-EET by CYP(4) - Homo sapiens [Reaction:R-HSA-2161794] Arachidonate is converted to HXA3/B3 by ALOX12 - Homo sapiens [Reaction:R-HSA-2162002] Arachidonate is oxidised to 15S-HpETE by ALOX15/15B - Homo sapiens [Reaction:R-HSA-265296] Arachidonate is oxidised to 5S-HpETE by ALOX5 - Homo sapiens
inferredFrom	[Reaction:R-MMU-9915559] Slc27a1 transports arachidonate across the ER membrane - Mus musculus
input	[SimpleEntity:R-ALL-140356] AA [endoplasmic reticulum lumen]
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:9915550] Impact on fatty acid metabolism and differential localization of FATP1 and FAT/CD36 proteins delivered in cultured human muscle cells [LiteratureReference:428991] How is the level of free arachidonic acid controlled in mammalian cells? [LiteratureReference:9915538] Expression cloning and characterization of a novel adipocyte long chain fatty acid transport protein
maxDepth	1
modified	[InstanceEdit:9917361] D'Eustachio, Peter, 2024-08-02
name	SLC27A1 transports arachidonate across the ER membrane (5Z,8Z,11Z,14Z)-eicosatetraenoate(out) = (5Z,8Z,11Z,14Z)-eicosatetraenoate(in)
output	[SimpleEntity:R-ALL-29768] AA [cytosol]
precedingEvent	[Reaction:R-HSA-111883] PLA2G4A (cPLA2) hydrolyzes phosphatidylcholine - Homo sapiens
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2012-12-04
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2569042] Rush, MG, 2012-11-10 [InstanceEdit:9917333] Hill, David P, 2024-08-02
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-428990
summation	[Summation:428987] Cytosolic arachidonate (AA) released by phospholipases is tr...
updateTrackers	[UpdateTracker:9919466] Update Tracker - [Reaction:428990] SLC27A1 transports arachidonate across the ER membrane - v90:[modifyText, removeCatalystActivity, removeLiteratureReference]

(updatedInstance)	[UpdateTracker:9919466] Update Tracker - [Reaction:428990] SLC27A1 transports arachidonate across the ER membrane - v90:[modifyText, removeCatalystActivity, removeLiteratureReference]
(precedingEvent)	[Reaction:R-HSA-2161948] Arachidonate is converted to 12-oxoETE by ALOX12 [Reaction:R-HSA-2161964] Arachidonate is oxidised to 12S-HpETE by ALOX12/15 [Reaction:R-HSA-2161950] Arachidonate is oxidised to 12R-HpETE by ALOX12B [Reaction:R-HSA-2161951] Arachidonate is oxidised to 15R-HETE by Acetyl-PTGS2 [Reaction:R-HSA-9915997] Arachidonate is epoxidated to 14,15-EET by CYP(5) [Reaction:R-HSA-2161899] Arachidonate is epoxidated to 8,9-EET by CYP(5) [Reaction:R-HSA-9915971] Arachidonate is epoxidated to 11,12-EET by CYP(5) [Reaction:R-HSA-2161890] Arachidonate is epoxidated to 5,6-EET by CYP(4) [Reaction:R-HSA-2161794] Arachidonate is converted to HXA3/B3 by ALOX12 [Reaction:R-HSA-265296] Arachidonate is oxidised to 5S-HpETE by ALOX5 [Reaction:R-HSA-2162002] Arachidonate is oxidised to 15S-HpETE by ALOX15/15B
(hasEvent)	[Pathway:R-HSA-2142753] Arachidonate metabolism
(inferredTo)	[Reaction:R-MMU-9915559] Slc27a1 transports arachidonate across the ER membrane

SLC27A1 transports arachidonate across the ER membrane Show undefined attributes

Referrals