Reactome | Arachidonate is epoxidated to 8,9-EET by CYP(5)

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Arachidonate is epoxidated to 8,9-EET by CYP(5) Show undefined attributes

authored	[InstanceEdit:2142839] Williams, MG, 2012-02-24
catalystActivity	[CatalystActivity:2161882] monooxygenase activity of CYP(5) [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:70101] cytosol
created	[InstanceEdit:2161780] Williams, MG, 2012-03-14
crossReference	[DatabaseIdentifier:9915974] RHEA:64985
dbId	2161899
displayName	Arachidonate is epoxidated to 8,9-EET by CYP(5)
edited	[InstanceEdit:2142839] Williams, MG, 2012-02-24
eventOf	[Pathway:R-HSA-2142670] Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) - Homo sapiens
followingEvent	[Reaction:R-HSA-9915968] 8,9-EET is hydrolysed to 8.9-DHET by EPHX2 - Homo sapiens
input	[SimpleEntity:R-ALL-29768] AA [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29364] NADPH [cytosol] [SimpleEntity:R-ALL-29368] O2 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:2162004] Metabolism of retinoids and arachidonic acid by human and mouse cytochrome P450 1b1 [LiteratureReference:2161833] Analysis of cytochrome P450 metabolites of arachidonic and linoleic acids by liquid chromatography-mass spectrometry with ion trap MS [LiteratureReference:2161944] Arachidonic acid metabolism by human cytochrome P450s 2C8, 2C9, 2E1, and 1A2: regioselective oxygenation and evidence for a role for CYP2C enzymes in arachidonic acid epoxygenation in human liver microsomes [LiteratureReference:215077] Molecular cloning and expression of CYP2J2, a human cytochrome P450 arachidonic acid epoxygenase highly expressed in heart
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	Arachidonate is epoxidated to 8,9-EET by CYP(5) 5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced (NADPH--hemoprotein reductase) => 8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized (NADPH--hemoprotein reductase)
orthologousEvent	[Reaction:R-DDI-2161899] Arachidonate is epoxidated to 8,9-EET by CYP(5) - Dictyostelium discoideum [Reaction:R-CEL-2161899] Arachidonate is epoxidated to 8,9-EET by CYP(5) - Caenorhabditis elegans [Reaction:R-GGA-2161899] Arachidonate is epoxidated to 8,9-EET by CYP(5) - Gallus gallus [Reaction:R-DRE-2161899] Arachidonate is epoxidated to 8,9-EET by CYP(5) - Danio rerio [Reaction:R-SSC-2161899] Arachidonate is epoxidated to 8,9-EET by CYP(5) - Sus scrofa [Reaction:R-BTA-2161899] Arachidonate is epoxidated to 8,9-EET by CYP(5) - Bos taurus [Reaction:R-CFA-2161899] Arachidonate is epoxidated to 8,9-EET by CYP(5) - Canis familiaris [Reaction:R-RNO-2161899] Arachidonate is epoxidated to 8,9-EET by CYP(5) - Rattus norvegicus [Reaction:R-MMU-2161899] Arachidonate is epoxidated to 8,9-EET by CYP(5) - Mus musculus
output	[SimpleEntity:R-ALL-2142662] 8,9-EET [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-29366] NADP+ [cytosol]
precedingEvent	[Reaction:R-HSA-428990] SLC27A1 transports arachidonate across the ER membrane - Homo sapiens
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2012-12-04
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2569042] Rush, MG, 2012-11-10 [InstanceEdit:9917333] Hill, David P, 2024-08-02
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2161899
summation	[Summation:2161777] Several cytochrome P450s (CYPs) convert arachidonate to 8,9-...
updateTrackers	[UpdateTracker:9919339] Update Tracker - [Reaction:2161899] Arachidonate is epoxidated to 8,9-EET by CYP(5) - v90:[add_removeOutput, modifyText]

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(updatedInstance)	[UpdateTracker:9919339] Update Tracker - [Reaction:2161899] Arachidonate is epoxidated to 8,9-EET by CYP(5) - v90:[add_removeOutput, modifyText]
(hasEvent)	[Pathway:R-HSA-2142670] Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)
(precedingEvent)	[Reaction:R-HSA-9915968] 8,9-EET is hydrolysed to 8.9-DHET by EPHX2