Reactome | Arachidonate is oxidised to 5S-HpETE by ALOX5

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Arachidonate is oxidised to 5S-HpETE by ALOX5 Show undefined attributes

authored	[InstanceEdit:378946] Jassal, Bijay, 2008-10-01
catalystActivity	[CatalystActivity:265275] oxidoreductase activity of ALOX5:ALOX5AP:LTC4S [nuclear envelope]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:13231] nuclear envelope
created	[InstanceEdit:265270] Jassal, B, 2008-04-17 12:12:14
crossReference	[DatabaseIdentifier:12668272] RHEA:17486 [DatabaseIdentifier:9915839] RHEA:17486
dbId	265296
displayName	Arachidonate is oxidised to 5S-HpETE by ALOX5
edited	[InstanceEdit:266011] Jassal, B, 2008-04-21 14:30:22
eventOf	[Pathway:R-HSA-2142688] Synthesis of 5-eicosatetraenoic acids - Homo sapiens [Pathway:R-HSA-2142691] Synthesis of Leukotrienes (LT) and Eoxins (EX) - Homo sapiens
followingEvent	[Reaction:R-HSA-2161946] 5S-HpETE is reduced to 5S-HETE by GPX1/2/4 - Homo sapiens [Reaction:R-HSA-266051] 5S-HpETE is dehydrated to LTA4 by ALOX5 - Homo sapiens
input	[SimpleEntity:R-ALL-29768] AA [cytosol] [SimpleEntity:R-ALL-29368] O2 [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:265274] Reversible, calcium-dependent membrane association of human leukocyte 5-lipoxygenase [LiteratureReference:265292] Characterization of cloned human leukocyte 5-lipoxygenase expressed in mammalian cells [LiteratureReference:265278] Single protein from human leukocytes possesses 5-lipoxygenase and leukotriene A4 synthase activities
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	Arachidonate is oxidised to 5S-HpETE by ALOX5 (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate Oxidation of arachidonic acid to 5-HpETE
orthologousEvent	[Reaction:R-DDI-265296] Arachidonate is oxidised to 5S-HpETE by ALOX5 - Dictyostelium discoideum [Reaction:R-GGA-265296] Arachidonate is oxidised to 5S-HpETE by ALOX5 - Gallus gallus [Reaction:R-XTR-265296] Arachidonate is oxidised to 5S-HpETE by ALOX5 - Xenopus tropicalis [Reaction:R-DRE-265296] Arachidonate is oxidised to 5S-HpETE by ALOX5 - Danio rerio [Reaction:R-SSC-265296] Arachidonate is oxidised to 5S-HpETE by ALOX5 - Sus scrofa [Reaction:R-BTA-265296] Arachidonate is oxidised to 5S-HpETE by ALOX5 - Bos taurus [Reaction:R-RNO-265296] Arachidonate is oxidised to 5S-HpETE by ALOX5 - Rattus norvegicus [Reaction:R-MMU-265296] Arachidonate is oxidised to 5S-HpETE by ALOX5 - Mus musculus
output	[SimpleEntity:R-ALL-266010] 5S-HpETE [cytosol]
precedingEvent	[Reaction:R-HSA-429016] ALOX5 is phosphorylated by MAPKAP2 - Homo sapiens [Reaction:R-HSA-428990] SLC27A1 transports arachidonate across the ER membrane - Homo sapiens
releaseDate	2008-12-17
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2569042] Rush, MG, 2012-11-10
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-265296
summation	[Summation:265288] Arachidonate 5-lipoxygenase (ALOX5) catalyzes the formation ...
updateTrackers	[UpdateTracker:9919394] Update Tracker - [Reaction:265296] Arachidonate is oxidised to 5S-HpETE by ALOX5 - v90:[modifyText] [UpdateTracker:9788638] Update Tracker - [Reaction:265296] Arachidonic acid is oxidised to 5S-HpETE by ALOX5 - v41:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9919394] Update Tracker - [Reaction:265296] Arachidonate is oxidised to 5S-HpETE by ALOX5 - v90:[modifyText] [UpdateTracker:9788638] Update Tracker - [Reaction:265296] Arachidonic acid is oxidised to 5S-HpETE by ALOX5 - v41:[modifyText]
(hasEvent)	[Pathway:R-HSA-2142691] Synthesis of Leukotrienes (LT) and Eoxins (EX) [Pathway:R-HSA-2142688] Synthesis of 5-eicosatetraenoic acids
(precedingEvent)	[Reaction:R-HSA-2161946] 5S-HpETE is reduced to 5S-HETE by GPX1/2/4 [Reaction:R-HSA-266051] 5S-HpETE is dehydrated to LTA4 by ALOX5