Reactome | Arachidonate is oxidised to 12S-HpETE by ALOX12/15

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Arachidonate is oxidised to 12S-HpETE by ALOX12/15 Show undefined attributes

authored	[InstanceEdit:2142839] Williams, MG, 2012-02-24
catalystActivity	[CatalystActivity:2162014] arachidonate 12(S)-lipoxygenase activity of ALOX12/15 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:2161780] Williams, MG, 2012-03-14
crossReference	[DatabaseIdentifier:12668404] RHEA:10429 [DatabaseIdentifier:9915894] RHEA:10429
dbId	2161964
displayName	Arachidonate is oxidised to 12S-HpETE by ALOX12/15
edited	[InstanceEdit:2142839] Williams, MG, 2012-02-24
eventOf	[Pathway:R-HSA-2142712] Synthesis of 12-eicosatetraenoic acid derivatives - Homo sapiens
followingEvent	[Reaction:R-HSA-2161999] 12S-HpETE is reduced to 12S-HETE by GPX1/2/4 - Homo sapiens
input	[SimpleEntity:R-ALL-29768] AA [cytosol] [SimpleEntity:R-ALL-29368] O2 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:2162036] Molecular cloning, primary structure, and expression of the human platelet/erythroleukemia cell 12-lipoxygenase [LiteratureReference:2161761] Cloning of the cDNA for human 12-lipoxygenase [LiteratureReference:2162025] Overexpression, purification and characterization of human recombinant 15-lipoxygenase [LiteratureReference:2161955] Expression of cloned human reticulocyte 15-lipoxygenase and immunological evidence that 15-lipoxygenases of different cell types are related
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	Arachidonate is oxidised to 12S-HpETE by ALOX12/15 (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate
orthologousEvent	[Reaction:R-DDI-2161964] Arachidonate is oxidised to 12S-HpETE by ALOX12/15 - Dictyostelium discoideum [Reaction:R-DRE-2161964] Arachidonate is oxidised to 12S-HpETE by ALOX12/15 - Danio rerio [Reaction:R-SSC-2161964] Arachidonate is oxidised to 12S-HpETE by ALOX12/15 - Sus scrofa [Reaction:R-BTA-2161964] Arachidonate is oxidised to 12S-HpETE by ALOX12/15 - Bos taurus [Reaction:R-CFA-2161964] Arachidonate is oxidised to 12S-HpETE by ALOX12/15 - Canis familiaris [Reaction:R-RNO-2161964] Arachidonate is oxidised to 12S-HpETE by ALOX12/15 - Rattus norvegicus [Reaction:R-MMU-2161964] Arachidonate is oxidised to 12S-HpETE by ALOX12/15 - Mus musculus
output	[SimpleEntity:R-ALL-2142811] 12S-HpETE [cytosol]
precedingEvent	[Reaction:R-HSA-428990] SLC27A1 transports arachidonate across the ER membrane - Homo sapiens
releaseDate	2012-03-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2569042] Rush, MG, 2012-11-10
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2161964
summation	[Summation:2161875] Arachidonate 12-lipoxygenase, 12S-type (ALOX12) (Funk et al....
updateTrackers	[UpdateTracker:9919463] Update Tracker - [Reaction:2161964] Arachidonate is oxidised to 12S-HpETE by ALOX12/15 - v90:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9919463] Update Tracker - [Reaction:2161964] Arachidonate is oxidised to 12S-HpETE by ALOX12/15 - v90:[modifyText]
(precedingEvent)	[Reaction:R-HSA-2161999] 12S-HpETE is reduced to 12S-HETE by GPX1/2/4
(hasEvent)	[Pathway:R-HSA-2142712] Synthesis of 12-eicosatetraenoic acid derivatives

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